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Published on: October 13, 2023
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Local inflammatory response in colorectal cancer
P Łaskowski1, B Klim, K Ostrowski
1Paweł Łaskowski, Department of Human Anatomy, Medical University of Bialystok, Mickiewicza 2 A, 15-089 Bialystok, Poland,
Summary
High numbers of tumor-infiltrating lymphocytes (TILs) near colorectal cancer tumors indicate a better prognosis. This suggests immunotherapy could be beneficial for treating colorectal cancer.
Area of Science:
- Immunology
- Oncology
- Pathology
Background:
- Tumor-infiltrating lymphocytes (TILs) play a crucial role in anti-tumor immunity.
- The prognostic significance of TILs in colorectal cancer (CRC) requires further elucidation.
Purpose of the Study:
- To investigate the prognostic value of TILs in postoperative colorectal cancer patients.
- To correlate TIL intensity with clinicopathological features of CRC.
Main Methods:
- Analysis of 66 postoperative colorectal cancer patients and 20 control colon segments.
- Immunohistochemical staining using monoclonal antibodies (LCA, CD3, CD4, CD5, CD8, CD20, CD23, CD138) to identify T and B lymphocytes.
- Quantification and characterization of TILs in proximity to the primary tumor.
Main Results:
- Significantly higher numbers of T and B lymphocytes were observed in proximity to cancerous tissue compared to controls.
- Increased T lymphocyte intensity correlated with larger tumor size, lymph node metastasis, and higher histological grade.
- Greater TIL intensity near the primary tumor was associated with less advanced colorectal cancer stages.
Conclusions:
- A direct relationship exists between the immune system and colorectal cancer.
- The presence of TILs near the primary tumor is a prognostically beneficial factor in colorectal cancer.
- Findings support the potential application of immunotherapy in colorectal cancer treatment.
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