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Related Experiment Video

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Magnetic Resonance Imaging of Multiple Sclerosis at 7.0 Tesla
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Comparison of two quantitative proton density mapping methods in multiple sclerosis.

René-Maxime Gracien1,2, Sarah C Reitz3,4, Marlies Wagner5,4

  • 1Department of Neurology, Goethe University, Frankfurt/Main, Germany. Rene-Maxime.Gracien@kgu.de.

Magma (New York, N.Y.)
|August 22, 2016
PubMed
Summary
This summary is machine-generated.

An alternative method for proton density (PD) mapping using T1-maps accurately corrects for receive profiles (RP) in multiple sclerosis (MS) patients. This approach provides reliable PD values, even with variations in patient disability.

Keywords:
Fatouros equationProton densityQuantitative MRIRelapsing-remitting multiple sclerosis

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Area of Science:

  • Magnetic Resonance Imaging (MRI)
  • Neuroimaging
  • Biomedical Engineering

Background:

  • Proton density (PD) mapping in MRI requires receive profile (RP) correction.
  • Bias-field correction is a common RP correction method.
  • An alternative RP-mapping method uses T1-map-derived values (ρ(T1)) via the Fatouros equation.

Purpose of the Study:

  • To evaluate the accuracy of an alternative RP-mapping method in multiple sclerosis (MS) patients.
  • To determine if ρ(T1) derived from T1-maps is reliable for PD mapping in MS.
  • To compare PD values obtained from the alternative method (PDalt) with a reference bias-field method (PDref).

Main Methods:

  • PD mapping was conducted on 27 relapsing-remitting MS patients and 27 healthy controls.
  • Both bias-field correction (PDref) and the alternative ρ(T1)-based method (PDalt) were applied.
  • Voxel-wise correlation between PDref and ρ(T1) was analyzed, considering patient disability levels.

Main Results:

  • PDalt values closely matched PDref in both MS patients and controls.
  • ρ(T1) showed discrepancies of up to 3% compared to PDref.
  • Reduced correlation between PDref and ρ(T1) was observed in MS patients with higher disability, but normalization minimized discrepancies.

Conclusions:

  • The alternative RP correction method using ρ(T1) yields accurate PD values in MS patients.
  • This method is effective despite potential discrepancies between ρ(T1) and actual PD values.
  • Accurate PD mapping is achievable in MS patients using this T1-map-based approach.