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Related Experiment Video

Updated: Mar 16, 2026

Assessment of the Metabolic Effects of Isocaloric 2:1 Intermittent Fasting in Mice

Assessment of the Metabolic Effects of Isocaloric 2:1 Intermittent Fasting in Mice

Published on: November 27, 2019

Calorie restriction in humans: An update.

Jasper Most¹, Valeria Tosti², Leanne M Redman¹

¹Reproductive Endocrinology and Women's Health, Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, LA 70808, USA.

Ageing Research Reviews

|August 22, 2016

Summary

Calorie restriction (CR), a diet with reduced energy intake, shows promise in humans for improving metabolic health and potentially extending lifespan. Studies in non-obese individuals reveal CR

Keywords:

Age-associated diseases Aging CALERIE Calorie restriction Energy metabolism Metabolic adaptation

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Related Experiment Videos

Last Updated: Mar 16, 2026

Assessment of the Metabolic Effects of Isocaloric 2:1 Intermittent Fasting in Mice

Assessment of the Metabolic Effects of Isocaloric 2:1 Intermittent Fasting in Mice

Published on: November 27, 2019

Solid Plate-based Dietary Restriction in Caenorhabditis elegans

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Published on: May 28, 2011

Determining Basal Energy Expenditure and the Capacity of Thermogenic Adipocytes to Expend Energy in Obese Mice

Determining Basal Energy Expenditure and the Capacity of Thermogenic Adipocytes to Expend Energy in Obese Mice

Published on: November 11, 2021

Area of Science:

Nutritional Science
Longevity Research
Metabolic Health

Background:

Calorie restriction (CR) is a dietary intervention involving reduced energy intake with adequate nutrition.
CR has demonstrated lifespan and healthspan extension in animal models.
Human studies suggest CR induces similar beneficial metabolic and molecular adaptations.

Purpose of the Study:

To discuss the physiological effects of CR in non-obese humans.
To detail findings from clinical trials on CR's feasibility and impact on energy metabolism and age-associated disease risk factors.
To explore potential longer-term effects of severe CR based on observational data.

Main Methods:

Review of observational and randomized clinical trials on CR in humans.
Analysis of data from young and middle-aged men and women participating in CR intervention trials.
Examination of data from individuals naturally practicing or self-adhering to CR.

Main Results:

CR in humans ameliorates key metabolic and hormonal factors linked to type 2 diabetes, cardiovascular diseases, and cancer.
Clinical trials investigate the feasibility and effects of CR on energy metabolism and metabolic risk factors.
Data suggests CR induces adaptations similar to those observed in animal longevity models.

Conclusions:

Moderate CR in non-obese humans positively impacts physiological parameters related to age-associated diseases.
CR interventions show feasibility in young and middle-aged populations.
Further research can elucidate the long-term effects of more severe CR in humans.