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lncRNA - Long Non-coding RNAs

lncRNA - Long Non-coding RNAs

In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...

Auditory Pathway

Auditory Pathway

Auditory pathways constitute the complex neural circuits responsible for transmitting and interpreting auditory information from the peripheral auditory system to the brain. Sound waves are initially captured by the outer ear, funneled through the ear canal, and reach the tympanic membrane (eardrum). These vibrations are transmitted via the middle ear's ossicles to the inner ear's cochlea.
When viewed cross-sectionally, the cochlea reveals the scala vestibuli and scala tympani flanking...

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Related Experiment Video

Updated: Mar 16, 2026

Auditory Brainstem Response and Outer Hair Cell Whole-cell Patch Clamp Recording in Postnatal Rats

Auditory Brainstem Response and Outer Hair Cell Whole-cell Patch Clamp Recording in Postnatal Rats

Published on: May 24, 2018

lncRNA expression in the auditory forebrain during postnatal development.

Yan Guo¹, Pan Zhang¹, Quanhu Sheng¹

¹Dept. of Cancer Biology, Vanderbilt University, Nashville, TN, USA.

|August 22, 2016

Summary

This summary is machine-generated.

Long noncoding RNAs (lncRNAs) show specific expression patterns in the developing mouse auditory forebrain. These lncRNAs interact with protein-coding RNAs, suggesting a key regulatory role in brain maturation.

Keywords:

Brain Cortex Development Maturation Neuromodulation Neurotransmission Non-coding RNA Plasticity Sensory Sequencing Synapse Thalamus Transcriptome lncRNA

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Last Updated: Mar 16, 2026

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Published on: May 24, 2018

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Area of Science:

Neuroscience
Molecular Biology
Genetics

Background:

Brain development relies on intricate gene and protein expression patterns.
Long noncoding RNAs (lncRNAs) are crucial regulators in biological processes.
The role of lncRNAs in sensory system development remains understudied.

Purpose of the Study:

To profile lncRNA expression in the mouse auditory forebrain during postnatal development.
To investigate the spatial and temporal specificity of lncRNA expression.
To explore interactions between lncRNAs, protein-coding RNAs (pcRNAs), and proteins.

Main Methods:

Profiling of lncRNA expression in the primary auditory cortex (A1) and medial geniculate body (MG) at postnatal days P7, P14, P21, and adulthood.
Differential expression analysis based on brain region and age.
Correlation and predictive analyses of lncRNA-pcRNA and lncRNA-protein interactions.
Construction of a user-friendly database for expression data.

Main Results:

Distinct lncRNA expression profiles were observed between brain regions (A1 vs. MG) and across developmental time points.
lncRNA expression exhibited significant spatial and temporal specificity during auditory forebrain maturation.
Many lncRNA-pcRNA pairs showed highly correlated maturational trajectories, indicating strong functional interactions.

Conclusions:

This study provides a comprehensive overview of lncRNA expression dynamics in the developing auditory forebrain.
lncRNAs play a significant role in the spatial and temporal regulation of auditory system development.
The findings establish a foundation for future research into lncRNA functions in neurodevelopment.