Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Allergic Reactions02:06

Allergic Reactions

33.3K
Overview
33.3K
Allergic Reactions: Anaphylaxis01:30

Allergic Reactions: Anaphylaxis

111
Anaphylaxis is a severe, life-threatening hypersensitivity reaction mediated by Immunoglobulin E (IgE) antibodies. When IgE binds to allergens, it triggers the release of mediators– histamine, leukotrienes, and prostaglandins from mast cells and basophils. These mediators cause vasodilation, edema, and inflammation, leading to various symptoms.The primary allergens causing anaphylaxis include food items (e.g., peanuts, shellfish), drugs (e.g., penicillin, asparaginase, corticotropin,...
111
Allergic Drug Reactions01:27

Allergic Drug Reactions

1.6K
Allergic reactions related to drugs are hypersensitivity responses driven by the immune system and bear no connection to the drug's therapeutic action. While drugs in isolation do not trigger an immune response, they can interact with endogenous proteins to form antigens. These antigens stimulate lymphocytes to produce antibodies. IgE-type antibodies attach themselves to mast cells. Upon subsequent exposure to the same stimulus, the antigen-antibody interaction is initiated, unleashing...
1.6K
Drug Toxicity: Allergic Reactions01:30

Drug Toxicity: Allergic Reactions

91
Drug-related allergies are immune-mediated responses triggered by the administration of pharmacological agents. These hypersensitivity reactions are classified based on the immune mechanisms involved. The four primary types—Type I, II, III, and IV—are mediated by different immunological pathways and exhibit distinct clinical manifestations.Type I Hypersensitivity/ IgE-Mediated Reactions: Immunoglobulin E (IgE) immediately mediates Type I hypersensitivity reactions. Upon initial...
91
Antibody Structure01:10

Antibody Structure

67.0K
Overview
Antibodies, also known as immunoglobulins (Ig), are essential players of the adaptive immune system. These antigen-binding proteins are produced by B cells and make up 20 percent of the total blood plasma by weight. In mammals, antibodies fall into five different classes, which each elicits a different biological response upon antigen binding.
The Y-Shaped Structure of Antibodies Consists of Four Polypeptide Chains
Antibodies consist of four polypeptide chains: two identical heavy...
67.0K
Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs01:25

Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs

2.2K
Asthma is a chronic respiratory condition for which new therapeutic avenues, including anti-inflammatory drugs like mast cell stabilizers and anti-IgE treatments, continue to be developed.
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
2.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Frailty Status and Outcomes in Patients with Acute Coronary Syndrome Undergoing Percutaneous Coronary Intervention: a multicentre retrospective cohort study.

European journal of cardiovascular nursing·2026
Same author

GLP-1 Receptor Agonists for Weight Loss and Risk of Major Safety Outcomes: A Multicentre Cohort Study.

Diabetes, obesity & metabolism·2026
Same author

Prenatal exposure to particulate matter and risk of autism spectrum disorder in children: a population-based cohort study in South Korea.

Environmental research·2026
Same author

Effect of post-discharge transitional care in patients with COPD: a multicenter single-blind randomised controlled trial.

BMC pulmonary medicine·2026
Same author

Impact of indoor exposure to particulate matter on the progression of idiopathic pulmonary fibrosis: a prospective multicentre cohort study protocol.

BMJ open respiratory research·2026
Same author

Prediction of low birth weight using machine learning-based analysis of environmental and maternal risk factors: insights from the Korean CHildren's ENvironmental health study (Ko-CHENS).

Environmental research·2026

Related Experiment Video

Updated: Mar 16, 2026

Symptom Assessment of Patients with Allergic Rhinitis Using an Allergen Exposure Chamber
08:47

Symptom Assessment of Patients with Allergic Rhinitis Using an Allergen Exposure Chamber

Published on: March 3, 2023

3.1K

Interaction Between Allergy and Middle Ear Infection.

Jeong-Hoon Oh1, Woo Jin Kim2

  • 1Department of Otorhinolaryngology-Head and Neck Surgery, College of Medicine, St. Paul's Hospital, The Catholic University of Korea, 180 Wangsan-ro, Dongdaemun-gu, Seoul, 02559, Republic of Korea. ojhent@catholic.ac.kr.

Current Allergy and Asthma Reports
|August 22, 2016
PubMed
Summary
This summary is machine-generated.

Allergy and infection interact to cause otitis media with effusion (OME). This review explores how host and environmental factors influence OME development, highlighting allergy

Keywords:
Acquired immunityAllergyInfectionInnate immunityOtitis media with effusion

More Related Videos

Acupoint Catgut Embedding Therapy in Traditional Chinese Medicine for Managing Allergic Rhinitis
03:40

Acupoint Catgut Embedding Therapy in Traditional Chinese Medicine for Managing Allergic Rhinitis

Published on: December 20, 2024

1.6K
Author Spotlight: Efficacy of Auricular Pressure Bean Therapy in Reducing Wheezing Symptoms
02:34

Author Spotlight: Efficacy of Auricular Pressure Bean Therapy in Reducing Wheezing Symptoms

Published on: May 10, 2024

2.1K

Related Experiment Videos

Last Updated: Mar 16, 2026

Symptom Assessment of Patients with Allergic Rhinitis Using an Allergen Exposure Chamber
08:47

Symptom Assessment of Patients with Allergic Rhinitis Using an Allergen Exposure Chamber

Published on: March 3, 2023

3.1K
Acupoint Catgut Embedding Therapy in Traditional Chinese Medicine for Managing Allergic Rhinitis
03:40

Acupoint Catgut Embedding Therapy in Traditional Chinese Medicine for Managing Allergic Rhinitis

Published on: December 20, 2024

1.6K
Author Spotlight: Efficacy of Auricular Pressure Bean Therapy in Reducing Wheezing Symptoms
02:34

Author Spotlight: Efficacy of Auricular Pressure Bean Therapy in Reducing Wheezing Symptoms

Published on: May 10, 2024

2.1K

Area of Science:

  • Otolaryngology
  • Immunology
  • Allergy Research

Background:

  • Upper airway defense involves respiratory epithelium immunity and mechanical factors.
  • Impaired defenses from allergy or bacterial resistance increase susceptibility to respiratory and middle ear infections.

Purpose of the Study:

  • To review the interaction between allergy and infection in otitis media with effusion (OME).
  • To discuss host and environmental factors contributing to OME development.

Main Methods:

  • Literature review of recent studies on OME causes and interactions.
  • Analysis of genetic studies on Toll-like receptor signaling and middle ear infections.

Main Results:

  • Allergy induces middle ear inflammation and facilitates pathogen invasion.
  • Allergy impacts susceptibility to upper respiratory tract infections, including the middle ear.
  • Genetic variations in Toll-like receptor signaling are linked to OME risk and phenotypes.

Conclusions:

  • Allergy is a significant factor in OME pathogenesis, exacerbating infectious susceptibility.
  • Understanding the interplay of allergy, infection, and host/environmental factors is crucial for OME management.