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Rest-activity rhythm disruption in progressive supranuclear palsy.

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Circadian activity rhythms are disrupted in individuals with progressive supranuclear palsy (PSP). This disruption worsens with increased disease severity, impacting sleep and daily functioning.

Keywords:
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Area of Science:

  • Neuroscience
  • Sleep Medicine
  • Chronobiology

Background:

  • Progressive supranuclear palsy (PSP) affects the brainstem, a key area for sleep and circadian regulation.
  • Previous studies noted disruptions in blood pressure and body temperature rhythms in PSP patients.
  • The impact of PSP on circadian activity rhythms remained unclear.

Purpose of the Study:

  • To analyze rest-activity rhythms in individuals with PSP.
  • To determine the association between circadian activity rhythm disruption and PSP disease severity.

Main Methods:

  • Actigraphy wristbands and sleep diaries were used for up to 14 days in 17 PSP patients and 17 controls.
  • Circadian activity parameters (mesor, amplitude, f-ratio, stability, variability) were assessed.
  • Analyses controlled for sleep fragmentation, cognition, and depression, with PSP rating scale used for severity.

Main Results:

  • PSP patients exhibited significantly weaker circadian activity (lower mesor, amplitude, robustness, stability; higher variability) compared to controls.
  • Circadian rhythm disruption persisted after controlling for confounding factors.
  • Weaker circadian activity correlated with increased PSP disease severity.

Conclusions:

  • Circadian activity rhythms are demonstrably disrupted in individuals with PSP.
  • The severity of circadian disruption increases with disease progression in PSP.
  • This study provides the first description of circadian activity rhythms in PSP.