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Catheter Ablation in Combination With Left Atrial Appendage Closure for Atrial Fibrillation
Published on: February 26, 2013
[Association between the cardiovascular health score and new-onset atrial fibrillation]
1Department of Cardiology, Kailuan General Hospital, Tangshan 063000, China.
Insights
Higher cardiovascular health scores are linked to a lower risk of developing new-onset atrial fibrillation. Maintaining cardiovascular health can significantly reduce the chances of developing this heart rhythm disorder.
Area of Science:
- Cardiology
- Preventive Medicine
- Public Health
Background:
- Atrial fibrillation is a common arrhythmia with significant health implications.
- Cardiovascular health scores are increasingly recognized as indicators of overall cardiovascular well-being.
- Understanding modifiable factors influencing atrial fibrillation risk is crucial for prevention strategies.
Purpose of the Study:
- To investigate the association between cardiovascular health score and the incidence of new-onset atrial fibrillation.
- To determine if a higher cardiovascular health score correlates with a reduced risk of developing atrial fibrillation.
Main Methods:
- A cohort of 85,028 participants without a history of atrial fibrillation was analyzed.
- Participants were categorized into four groups based on their baseline cardiovascular health score (0-6, 7-8, 9-10, 11-14 points).
- Cox regression analysis was used to assess the relationship between cardiovascular health score and atrial fibrillation incidence over a median follow-up of 5.6 years.
Main Results:
- A total of 254 participants developed atrial fibrillation during the follow-up period.
- The incidence of atrial fibrillation decreased progressively with increasing cardiovascular health score.
- Each one-point increase in cardiovascular health score was associated with an 8% reduction in new-onset atrial fibrillation risk (HR=0.92).
- Participants with the highest score (11-14 points) had a 49% lower risk of atrial fibrillation compared to those with the lowest score (0-6 points).
Conclusions:
- Increasing cardiovascular health score is proportionally associated with a reduced risk of new-onset atrial fibrillation.
- Promoting cardiovascular health may be a key strategy in preventing atrial fibrillation.
- These findings underscore the importance of comprehensive cardiovascular health assessment and improvement.
Objective:
To observe the association between the cardiovascular health score and new-onset atrial fibrillation.
Methods:
A total of 95 026 participants who participated the health examination between July 2006 and October 2007 at Kailuan group and without history of atrial fibrillation were selected as the observation cohort. The second, the third and the fourth health examination were performed between July 2008 to October 2009, July 2010 to October 2011, July 2012 to October 2013, respectively.A total of 85 028 participants were included in the final analysis after excluding participants who had new-onset valvular atrial fibrillation and participants lost to follow-up. The participants were divided into 4 subgroups by cardiovascular health score at baseline according to the definition of AHA and cardiovascular health scoring system, namely group of 0-6 points (n=11 103), 7-8 points (n=24 487), 9-10 points (n=32 556), and 11-14 points (n=16 882). The incidence of atrial fibrillation in each subgroup was observed, and the association between cardiovascular health score and risk of new-onset atrial fibrillation was analyzed using multiple Cox regression analysis.
Results:
A total of 254 participants developed atrial fibrillation during the median of (5.6±1.4) years follow-up. The total incidence of new-onset atrial fibrillation was 0.53/1 000 person-year. The incidence of atrial fibrillation was 0.69/1 000 person-year, 0.60/1 000 person-year, 0.56/1 000 person-year, and 0.30/1 000 person-year, respectively in 0-6 points, 7-8 points, 9-10 points, and 11-14 points subgroups, respectively(P<0.01). After adjustment of age, gender, education level, income, drink, history of myocardial infarction, history of stroke, serum uric acid and C reactive protein level, multiple Cox regression analysis showed that one health score point increase was related to 8% reduction of new onset atrial fibrillation(HR=0.92, 95%CI 0.86-0.99, P<0.05). Compared with the group of 0-6 points group, the risk of atrial fibrillation in the group of 11-14 points group was reduced by 49% (HR=0.51, 95%CI 0.31-0.83, P<0.01).
Conclusion:
The risk of new-onset atrial fibrillation is reduced in proportion to increase of cardiovascular health score. Clinical Trail Registry: Chinese Clinical Trail Registry, ChiCTR-TNRC-11001489.
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