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Related Concept Videos

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The first thing a clinician sees is the skin, so the examination of the skin should be part of any thorough physical examination. Most skin disorders are relatively benign, but a few, including melanomas, can be fatal if untreated. A couple of the more noticeable disorders, albinism and vitiligo, affect the appearance of the skin and its accessory organs.
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Drug toxicities can be stratified into pharmacological, pathological, or genotoxic based on their mechanisms. The incidence and severity of these toxicities generally increase with the drug's concentration in the body and exposure time.Pharmacological toxicity is evident when the therapeutic effects of drugs overshoot into adverse reactions in a predictable, dose-dependent manner. Central nervous system (CNS) depression from barbiturates is a classic example, with effects escalating from...
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Related Experiment Video

Updated: Mar 16, 2026

Synthesis of Plant Phenol-derived Polymeric Dyes for Direct or Mordant-based Hair Dyeing
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Drug-induced hair colour changes.

Francesco Ricci1, Clara De Simone1, Laura Del Regno1

  • 1Institute of Dermatology, Catholic University of the Sacred Heart, Rome, Italy.

European Journal of Dermatology : EJD
|August 23, 2016
PubMed
Summary
This summary is machine-generated.

Systemic drugs can alter hair color, causing changes like lightening or darkening. Recognizing and reporting these uncommon but impactful side effects is crucial for patient care and treatment adherence.

Keywords:
drughair colour changeshair depigmentationhair hyperpigmentation

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Area of Science:

  • Pharmacology
  • Dermatology
  • Oncology

Background:

  • Hair color changes (lightening, darkening, greying) can occur with systemic medications.
  • While hair loss and hypertrichosis are known side effects, hair color alteration is less common.
  • The increasing use of targeted therapies necessitates attention to these adverse events.

Purpose of the Study:

  • To review the literature on systemic drugs associated with hair color modifications.
  • To highlight the importance of identifying and reporting drug-induced hair color changes.

Main Methods:

  • Literature review of systemic drugs causing hair color changes.
  • Analysis of established causality assessment algorithms for adverse drug reactions.

Main Results:

  • Hair color modification is an uncommon adverse effect of systemic medications.
  • Mechanisms underlying drug-induced hair color changes are often not fully understood.
  • Causality assessment algorithms aid in linking drug intake to observed side effects.

Conclusions:

  • Hair color changes, though not life-threatening, significantly impact patient quality of life and treatment adherence.
  • Systematic reporting of all adverse events, including hair color changes, is vital for the scientific community.
  • Further research into the mechanisms of drug-induced hair color modification is warranted.