Helicobacter pylori infection and iron deficiency in patients with coronary artery disease
S Fallah1, R Ahmadi2, N Moradi2
1Iran University of Medical Sciences Research center of Pediatric Infectious Disease, Rasool Akram Hospital Tehran Iran fallah.s@iums.ac.ir.
Insights
Helicobacter pylori (H pylori) infection is linked to lower ferritin and iron levels in cardiovascular disease patients, potentially indicating an independent risk factor for atherosclerosis. This suggests H pylori may contribute to cardiovascular pathologies through chronic inflammation.
Area of Science:
- Cardiovascular Medicine
- Infectious Diseases
- Biochemistry
Background:
- Cardiovascular disease (CVD) is a leading cause of mortality globally.
- Atherosclerosis is a primary pathological process underlying most CVD.
- The role of chronic infections, such as Helicobacter pylori (H pylori), in CVD pathogenesis is an area of ongoing research.
Purpose of the Study:
- To investigate the association between H pylori seropositivity and iron/ferritin levels in patients with cardiovascular disease.
- To determine if H pylori infection is an independent risk factor for atherosclerosis in CVD patients.
Main Methods:
- ELISA assay was used to measure anti-H pylori IgG and IgA levels, serum ferritin, and iron concentration.
- Study included 86 patients with cardiovascular disease and 64 healthy control subjects.
Main Results:
- H pylori IgG and IgA seropositivity was significantly higher in coronary artery disease (CAD) patients compared to controls.
- A significant negative correlation was observed between H pylori seropositivity and ferritin/iron levels in CAD patients.
- H pylori infection was associated with reduced ferritin and iron levels, independent of classic risk factors.
Conclusions:
- H pylori infection may contribute to atherosclerosis and CAD-related pathologies via chronic inflammation.
- Reduced ferritin and iron levels in H pylori-infected CAD patients represent a potential independent risk factor for atherosclerosis.
Abstract:
The aim of this study was to investigate whether impact of the seropositivity to Helicobacter pylori (H pylori) infection on ferritin and iron levels is an independent risk factor for atherosclerosis in patients with cardiovascular disease. The anti H pylori IgG, IgA levels, serum ferritin and iron concentration of 86 patients with cardiovascular disease and 64 participants free of cardiovascular disease as control subjects were determined by ELISA assay. The results of present study showed that seropositivity to H pylori IgG and IgA levels of coronary artery disease (CAD) patients was higher than controls and CAD patients with negative anti H pylori IgG and IgA significantly. A significant negative correlation was found between seropositivity to H pylori IgG and IgA, ferritin and iron levels of CAD patients with seronegativity and seronegativity to H pylori IgG and IgA in comparison with controls. The achieved results from present study suggest that the involvement of H pylori infection in atherosclerosis process is based on the chronic inflammation which might facilitate the CAD-related pathologies. Moreover, impact of the presence of H pylori infection on reduction of the ferritin and iron levels of CAD patients as a risk factor independent of other classic factors including lipid profiles and inflammatory factors was remarkable.
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