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Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...
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Related Experiment Video

Updated: Mar 16, 2026

Optimized Procedure for Determining the Adsorption of Phosphonates onto Granular Ferric Hydroxide using a Miniaturized Phosphorus Determination Method
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[Iron-based Phosphate Binders for ESRD Patients].

Mario Cozzolino, Michela Mangano, Lorenza Magagnoli

    Giornale Italiano Di Nefrologia : Organo Ufficiale Della Societa Italiana Di Nefrologia
    |August 23, 2016
    PubMed
    Summary
    This summary is machine-generated.

    Non-calcium phosphate binders, like sevelamer and lanthanum carbonate, are preferred for chronic kidney disease (CKD) patients to prevent bone disease progression. Newer iron-based binders offer additional options beyond calcium-based agents.

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    Area of Science:

    • Nephrology
    • Mineral and Bone Disorders

    Background:

    • Patient factors like age, gender, diabetes, and inflammation influence phosphate binder selection in chronic kidney disease (CKD).
    • Calcium-based phosphate binders may contribute to calcification, a concern in CKD management.
    • Adynamic bone is a potential complication in CKD patients requiring phosphate binders.

    Purpose of the Study:

    • To review the factors influencing phosphate binder choice in CKD patients.
    • To highlight the benefits of non-calcium-based phosphate binders over calcium-based ones.
    • To introduce newer phosphate-binding agents.

    Main Methods:

    • Literature review of factors affecting phosphate binder selection.
    • Comparison of calcium-based versus non-calcium-based phosphate binders.
    • Discussion of emerging iron-based phosphate binders.

    Main Results:

    • Non-calcium binders (sevelamer, lanthanum carbonate) reduce adynamic bone progression in CKD compared to calcium-based binders.
    • Focus is shifting towards non-calcium agents due to concerns about calcium's role in calcification.
    • Iron-based phosphate binders represent a new therapeutic option.

    Conclusions:

    • Non-calcium phosphate binders are crucial for managing bone disease in CKD patients.
    • Avoiding calcium-based binders may mitigate calcification risks.
    • The availability of diverse phosphate binders, including iron-based options, enhances CKD treatment strategies.