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Related Concept Videos

Allergic Reactions02:06

Allergic Reactions

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Allergic Reactions: Anaphylaxis01:30

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Anaphylaxis is a severe, life-threatening hypersensitivity reaction mediated by Immunoglobulin E (IgE) antibodies. When IgE binds to allergens, it triggers the release of mediators– histamine, leukotrienes, and prostaglandins from mast cells and basophils. These mediators cause vasodilation, edema, and inflammation, leading to various symptoms.The primary allergens causing anaphylaxis include food items (e.g., peanuts, shellfish), drugs (e.g., penicillin, asparaginase, corticotropin,...
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Antibody Structure01:10

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Antibodies, also known as immunoglobulins (Ig), are essential players of the adaptive immune system. These antigen-binding proteins are produced by B cells and make up 20 percent of the total blood plasma by weight. In mammals, antibodies fall into five different classes, which each elicits a different biological response upon antigen binding.
The Y-Shaped Structure of Antibodies Consists of Four Polypeptide Chains
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Allergic reactions related to drugs are hypersensitivity responses driven by the immune system and bear no connection to the drug's therapeutic action. While drugs in isolation do not trigger an immune response, they can interact with endogenous proteins to form antigens. These antigens stimulate lymphocytes to produce antibodies. IgE-type antibodies attach themselves to mast cells. Upon subsequent exposure to the same stimulus, the antigen-antibody interaction is initiated, unleashing...
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Drug Toxicity: Allergic Reactions01:30

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Drug-related allergies are immune-mediated responses triggered by the administration of pharmacological agents. These hypersensitivity reactions are classified based on the immune mechanisms involved. The four primary types—Type I, II, III, and IV—are mediated by different immunological pathways and exhibit distinct clinical manifestations.Type I Hypersensitivity/ IgE-Mediated Reactions: Immunoglobulin E (IgE) immediately mediates Type I hypersensitivity reactions. Upon initial...
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Related Experiment Video

Updated: Mar 16, 2026

Humanized Mediator Release Assay as a Read-Out for Allergen Potency
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Allergen Immunotherapy.

Efren Rael1

  • 1Sean N. Parker Center for Allergy and Asthma Research, Stanford University, Box 18885, Stanford, CA 94309, USA.

Primary Care
|August 23, 2016
PubMed
Summary

Allergies impact many people, affecting daily life and potentially causing severe reactions. Allergen immunotherapy offers a unique treatment to alter the course of allergic disease.

Area of Science:

  • Immunology
  • Allergy Research
  • Clinical Medicine

Background:

  • Allergies are prevalent, significantly impacting patient quality of life, productivity, and sleep.
  • Allergic conditions can manifest across multiple organ systems and range from mild to life-threatening.
  • Current treatments often manage symptoms, but do not alter the underlying disease progression.

Purpose of the Study:

  • To highlight the significant public health burden of allergies.
  • To emphasize the limitations of existing allergy management strategies.
  • To introduce allergen immunotherapy as a disease-modifying treatment.

Main Methods:

  • Review of existing epidemiological data on allergy prevalence.
  • Analysis of the impact of allergies on various aspects of daily living.
Keywords:
AeroallergenAllergy immunotherapyFood immunotherapyStandard subcutaneous immunotherapy (SCIT)Venom immunotherapy (VIT)

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  • Examination of the mechanisms and outcomes of allergen immunotherapy.

    • Main Results:

    • Allergies represent a substantial global health issue with widespread effects.
    • Severe allergic reactions pose a significant risk to patient health.
    • Allergen immunotherapy is the sole therapeutic option capable of modifying the natural progression of allergic diseases.

    Conclusions:

    • Allergen immunotherapy is a crucial intervention for altering the natural history of allergic disease.
    • Further research and clinical application of allergen immunotherapy are warranted.
    • Addressing the broad impact of allergies requires effective, disease-modifying treatments like immunotherapy.