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Association of interleukin 1 gene cluster and interleukin 1 receptor gene polymorphisms with ischemic heart failure

M J Mahmoudi, M Taghvaei, S Harsini

    Bratislavske Lekarske Listy
    |August 23, 2016
    PubMed

    Insights

    Genetic variations in the Interleukin-1 beta (IL-1β) gene may increase susceptibility to chronic heart failure (CHF) from ischemic heart disease. Specific IL-1β alleles and genotypes were more common in patients with this condition.

    Area of Science:

    • Genetics and Molecular Biology
    • Cardiovascular Medicine
    • Immunology

    Background:

    • Proinflammatory cytokines are implicated in the development of chronic heart failure (CHF).
    • The Interleukin-1 (IL-1) gene cluster, including IL-1α, IL-1β, and IL-1 receptor antagonist (IL-1RA), plays a role in inflammatory processes.
    • Investigating genetic polymorphisms in the IL-1 gene cluster may reveal insights into CHF pathogenesis.

    Purpose of the Study:

    • To determine if polymorphisms in the IL-1 gene cluster (IL-1α, IL-1β, IL-1RA, IL-1R) predict chronic heart failure (CHF) caused by ischemic heart disease.
    • To assess the association between specific single nucleotide polymorphisms (SNPs) and the risk of developing ischemic heart failure.

    Main Methods:

    • A case-control study comparing 43 patients with ischemic heart failure to 140 healthy controls.
    • Genotyping of 5 SNPs in the IL-1α, IL-1β, IL-1R, and IL-1RA genes using polymerase chain reaction with sequence-specific primers.
    • Analysis of allele and genotype frequencies between the patient and control groups.

    Main Results:

    • A significantly higher frequency of the IL-1β -511/C allele was observed in the ischemic heart failure patient group compared to controls (p = 0.031).
    • The IL-1β (-511) C/C genotype was significantly overrepresented in patients with ischemic heart failure versus controls (p = 0.022).

    Conclusions:

    • Specific alleles and genotypes within the IL-1β gene are more prevalent in patients with ischemic heart failure.
    • These genetic variations in IL-1β may contribute to an individual's susceptibility to developing ischemic heart failure.
    Abstract

    Keywords:
    heart failureinterleukin-1.single nucleotide polymorphism

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