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Multiple sclerosis: Pregnancy and women's health issues
M Mendibe Bilbao1, S Boyero Durán1, J Bárcena Llona1
1Departamento de Neurología, Hospital Universitario Cruces, Baracaldo, España.
Neurologia
|August 23, 2016
Summary
This review clarifies how sex, pregnancy, and hormones affect multiple sclerosis (MS). It offers guidance for managing MS in women before, during, and after pregnancy, and for future research.
Area of Science:
- Neuroimmunology
- Reproductive Medicine
- Clinical Neurology
Background:
- The clinical course of multiple sclerosis (MS) is significantly modulated by sex, pregnancy, and hormonal fluctuations.
- Understanding these influences is crucial for elucidating MS aetiopathogenic mechanisms.
Purpose of the Study:
- To analyze the impact of sex, pregnancy, and hormonal factors on multiple sclerosis.
- To clarify the underlying aetiopathogenic mechanisms of MS in relation to these factors.
Main Methods:
- Comprehensive literature review of PubMed using keywords: 'multiple sclerosis', 'MS', 'EAE', 'pregnancy', 'hormonal factors', 'treatment'.
- Inclusion of advances presented at ECTRIMS 2013 and expert recommendations.
Main Results:
- Current findings on treatment effects on mother, fetus, and newborn are presented.
- Recommendations for managing women with MS around pregnancy are formulated.
Conclusions:
- Provides counseling and treatment recommendations for women with MS undergoing pregnancy.
- Identifies knowledge gaps and inconsistencies, proposing future research directions.
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