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Related Experiment Video

Updated: Mar 16, 2026

Establishment and Characterization of Small Bowel Neuroendocrine Tumor Spheroids

Establishment and Characterization of Small Bowel Neuroendocrine Tumor Spheroids

Published on: October 14, 2019

Small Bowel Adenocarcinoma.

Thomas Aparicio¹, Aziz Zaanan², Florence Mary¹

¹Gastroenterology and Digestive Oncology Unit, Avicenne Hospital, HUPSSD, APHP, Université Paris 13, Sorbonne Paris Cité, 125 rue de Stalingrad, Bobigny 93000, France.

Gastroenterology Clinics of North America

|August 23, 2016

Summary

Small bowel adenocarcinomas (SBAs) are rare but increasing cancers. Research is exploring adjuvant chemotherapy and targeted therapies to improve outcomes for patients with this challenging diagnosis.

Keywords:

Carcinogenesis Chemotherapy Lynch syndrome Prognostic factor Rare tumor Small intestine adenocarcinoma

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Application of Robot-assisted Pancreaticobiliary Junction Resection in Benign Duodenal Tumors

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Area of Science:

Gastroenterology
Oncology

Background:

Small bowel adenocarcinomas (SBAs) are rare gastrointestinal tumors with increasing incidence.
The duodenum is the most common primary site for SBAs.
While often sporadic, certain diseases increase SBA risk, and early diagnosis remains challenging despite advances.

Purpose of the Study:

To summarize current knowledge on small bowel adenocarcinomas.
To highlight prognostic factors and emerging treatment strategies.

Main Methods:

Review of existing literature on small bowel adenocarcinoma.
Discussion of prognostic factors like lymph node invasion post-resection.
Overview of ongoing clinical trials and retrospective study findings.

Main Results:

Lymph node invasion is a key prognostic factor after R0 resection.
Platinum-based chemotherapy shows promise for metastatic SBA.
Ongoing studies are evaluating adjuvant chemotherapy (BALLAD trial) and targeted therapies.

Conclusions:

Adjuvant chemotherapy and targeted therapies are areas of active investigation for small bowel adenocarcinoma.
Improving early diagnosis and treatment efficacy remain critical goals in managing SBAs.