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Antibiotic treatment and resistance in chronic wounds of vascular origin
Valentina Tzaneva1, Irena Mladenova2, Galina Todorova1
1MHAT Trakia, Stara Zagora, Bulgaria.
Background And Aim:
The problem of antibiotic resistance is worldwide and affects many types of pathogens. This phenomenon has been growing for decades and nowadays we are faced with a wide range of worrisome pathogens that are becoming resistant and many pathogens that may soon be untreatable. The aim of this study was to determine the resistance and antibiotic treatment in chronic wounds of vascular origin.
Methods:
We performed a cross sectional study on a sample of patients with chronic vascular wounds, hospitalized between October 2014 and August 2015, in the Clinic of Vascular Surgery in Trakia Hospital Stara Zagora. The statistical analysis of data was descriptive, considering the p value of ≤0.05, the threshold of statistical significance.
Results:
In the group of 110 patients, the significantly most frequent chronic wound (p<0.001) was peripheral arteriopathy (47.3%, CI95%: 38.19-56.54). Among 159 strains, 30% of patients having multiple etiology, the species most frequently isolated were Staphylococcus aureus, E.coli, Enterococcus faecalis, Pseudomonas aeruginosa and Proteus mirabilis with a significant predominance (p<0.05) of the Gram negative (55.1%). The spectrum of strains resistance included the Beta-lactams (36.4%, p<0.001), Macrolides (20%), Tetracyclines (9.1%), Aminoglycosides (8.2%) and Fluoroquinolones (4.5%).
Conclusions:
Gram negative microorganisms were the main isolates in patients with vascular chronic wound. Significantly predominant was the resistance to the beta-lactam antibiotics.
Insights
Antibiotic resistance is a growing global threat. This study found Gram-negative bacteria were most common in vascular wounds, with significant resistance to beta-lactam antibiotics.
Area of Science:
- Medical Microbiology
- Infectious Diseases
- Vascular Surgery
Background:
- Antibiotic resistance poses a significant worldwide challenge, impacting numerous pathogens.
- Increasing antimicrobial resistance threatens effective treatment of infections, including chronic wounds.
- Vascular wounds are particularly susceptible to infections and complications from resistant bacteria.
Purpose of the Study:
- To investigate antibiotic resistance patterns in chronic vascular wounds.
- To identify prevalent microbial strains and their susceptibility to various antibiotic classes.
- To inform antibiotic treatment strategies for patients with vascular-related chronic wounds.
Main Methods:
- A cross-sectional study was conducted on 110 patients with chronic vascular wounds.
- Bacterial isolates were identified from wound samples collected between October 2014 and August 2015.
- Statistical analysis included descriptive statistics and significance testing (p≤0.05).
Main Results:
- Peripheral arteriopathy was the most frequent chronic wound type (47.3%).
- Staphylococcus aureus, E.coli, Enterococcus faecalis, Pseudomonas aeruginosa, and Proteus mirabilis were the most common isolates.
- Gram-negative bacteria predominated (55.1%), with significant resistance observed against Beta-lactams (36.4%).
Conclusions:
- Gram-negative microorganisms are the primary isolates in chronic vascular wounds.
- Resistance to beta-lactam antibiotics was notably prevalent in the studied population.
- Understanding these resistance patterns is crucial for effective wound management.
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