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Kidney Transplant I: Introduction

Kidney Transplant I: Introduction

A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...

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Related Experiment Video

Updated: Mar 16, 2026

Epithelial Cell Repopulation and Preparation of Rodent Extracellular Matrix Scaffolds for Renal Tissue Development

Epithelial Cell Repopulation and Preparation of Rodent Extracellular Matrix Scaffolds for Renal Tissue Development

Published on: August 10, 2015

Autologous Cells for Kidney Bioengineering.

Bettina Wilm¹, Riccardo Tamburrini², Giuseppe Orlando²

¹Institute of Translational Medicine, Centre for Preclinical Imaging, University of Liverpool, Crown Street, Liverpool, L69 3BX UK.

Current Transplantation Reports

|August 23, 2016

Summary

This summary is machine-generated.

Bioengineered kidneys offer a promising alternative to dialysis and transplantation for end-stage renal disease. Utilizing autologous cells and scaffolds, this approach aims to create patient-specific kidneys, addressing donor shortages.

Keywords:

Bioprinting Decellularisation Induced pluripotent stem cells Kidney organoids Kidney scaffolds Renal progenitor cells

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Isogenic Kidney Glomerulus Chip Engineered from Human Induced Pluripotent Stem Cells

Isogenic Kidney Glomerulus Chip Engineered from Human Induced Pluripotent Stem Cells

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Related Experiment Videos

Last Updated: Mar 16, 2026

Epithelial Cell Repopulation and Preparation of Rodent Extracellular Matrix Scaffolds for Renal Tissue Development

Epithelial Cell Repopulation and Preparation of Rodent Extracellular Matrix Scaffolds for Renal Tissue Development

Published on: August 10, 2015

Microdissection of Primary Renal Tissue Segments and Incorporation with Novel Scaffold-free Construct Technology

Microdissection of Primary Renal Tissue Segments and Incorporation with Novel Scaffold-free Construct Technology

Published on: March 27, 2018

Isogenic Kidney Glomerulus Chip Engineered from Human Induced Pluripotent Stem Cells

Isogenic Kidney Glomerulus Chip Engineered from Human Induced Pluripotent Stem Cells

Published on: November 4, 2022

Area of Science:

Regenerative Medicine
Biotechnology
Urology

Background:

End-stage renal disease (ESRD) affects a growing global population, with limited treatment options like dialysis or transplantation.
Current treatments for ESRD, such as dialysis and kidney transplantation, present significant challenges including high morbidity, mortality, reduced quality of life, and substantial economic burdens.
The scarcity of donor kidneys for transplantation necessitates the exploration of alternative therapeutic strategies.

Approach:

This review explores the development of bioengineered kidneys using autologous cells and suitable scaffolds for transplantation.
Recent advancements in pluripotent stem cell technology have enabled the generation of autologous renal progenitor cells.
These progenitor cells possess the capacity to differentiate into all necessary renal cell types for constructing a functional kidney.

Key Points:

Bioengineering kidneys involves combining patient-derived cells with advanced scaffold materials.
Pluripotent stem cell breakthroughs are crucial for generating specific renal cell lineages.
The goal is to create patient-matched organs, circumventing immune rejection and donor limitations.

Conclusions:

Bioengineered kidneys represent a potential solution to the critical shortage of donor organs.
This innovative approach could significantly improve treatment outcomes and quality of life for ESRD patients.
Further research into cell-scaffold interactions is vital for clinical translation.