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Phases of Wound Repair

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Related Experiment Video

Updated: Mar 16, 2026

Author Spotlight: Studying Host-Microbe Interactions in Wound Biofilm Formation

Author Spotlight: Studying Host-Microbe Interactions in Wound Biofilm Formation

Published on: June 16, 2023

Wound bed preparation: TIME for an update.

Rhiannon L Harries¹, David C Bosanquet², Keith G Harding³

¹Royal College of Surgeons/Welsh Wound Initiative Research Fellow, Wound Healing Research Unit, School of Medicine, Cardiff University, Cardiff, UK.

International Wound Journal

|August 23, 2016

Summary

This summary is machine-generated.

Chronic wounds often fail to heal, causing significant health issues and high treatment costs. Effective wound bed preparation using the TIME (Tissue, Inflammation/infection, Moisture imbalance, Epithelial edge advancement) concept is crucial for successful healing.

Keywords:

Chronic wounds Wound bed preparation Wound healing

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Area of Science:

Wound healing research
Tissue regeneration
Chronic wound management

Background:

Most wounds heal quickly, but a substantial number develop into chronic wounds.
Chronic wounds lead to significant patient morbidity and impose high healthcare costs.
The TIME (Tissue, Inflammation/infection, Moisture imbalance, Epithelial edge advancement) concept provides a framework for managing chronic wounds.

Purpose of the Study:

To present an updated literature review on recent advancements in wound bed preparation.
To highlight the importance of addressing all TIME components for effective wound healing.
To discuss the clinical value of novel therapies in the context of wound bed preparation.

Main Methods:

Systematic literature review of recent studies on wound bed preparation.
Analysis of the TIME concept components: Tissue, Inflammation/infection, Moisture imbalance, and Epithelial edge advancement.
Evaluation of novel therapeutic options for chronic wound management.

Main Results:

Successful wound closure depends on optimizing each TIME component.
Many novel wound therapies lack sufficient clinical data to confirm their value.
Inadequate wound bed preparation is a common issue before initiating expensive treatments.

Conclusions:

Optimizing wound bed preparation is essential for chronic wound healing.
Clinicians must carefully assess the evidence for novel therapies before application.
A thorough understanding and application of the TIME concept are critical for improving patient outcomes in chronic wound care.