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Updated: Mar 16, 2026
A Novel Technique for Generating and Observing Chemiluminescence in a Biological Setting
Published on: March 9, 2017
Protein Nanocages for Delivery and Release of Luminescent Ruthenium(II) Polypyridyl Complexes
Xiao Li1, Yajie Zhang1, Hong Chen1,2
1Department of Polymer Science & Engineering, School of Chemistry & Chemical Engineering, Nanjing University , Nanjing 210023, P. R. China.
Abstract:
In this report, noncovalent encapsulation of hydrophobic ruthenium(II) polyridyl complexes, Ru(bpy)2dppz(2+) and Ru(phen)2dppz(2+), into apoferritin cavity was achieved with high loading contents by effective prevention of Ru complex-induced protein aggregation, without disruption of protein native architecture. The Ru-loaded luminescent nanocomposites have demonstrated improved water solubility, easy manipulation, reduced cytotoxicity, and enhanced cellular uptake as compared to the nontreated Ru complexes.
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