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Engineering Oncogenic Heterozygous Gain-of-Function Mutations in Human Hematopoietic Stem and Progenitor Cells

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Energy parasites trigger oncogene mutation.

Jiří Pokorný¹, Jan Pokorný¹, Anna Jandová²

¹a Institute of Physics, Czech Academy of Sciences , Prague , Czech Republic ;

International Journal of Radiation Biology

|August 23, 2016

Summary

This summary is machine-generated.

Parasitic virus energy consumption disrupts cellular electromagnetic fields, increasing random genome mutations and initiating cancer. This energy mechanism explains genome mutation and cancer development.

Keywords:

Cancer initiation LDH virus cell-mediated immunity coherent electromagnetic states genome somatic mutation parasitic energy consumption

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Area of Science:

Oncology
Virology
Biophysics

Background:

Cell-mediated immunity (CMI) analysis of 12,000 cases revealed similarities between cancer antigens and lactate dehydrogenase-elevating (LDH) virus.
LDH virus RNA impacts cellular electromagnetic fields, affecting DNA stability.
Precancerous cervical lesions (CIN) showed mixed CMI responses, indicating a transitional state.

Purpose of the Study:

To investigate the role of parasitic virus energy consumption in cancer initialization.
To explore the relationship between cellular electromagnetic fields, genome stability, and cancer development.
To elucidate the energy mechanism underlying genome mutation and cancer initiation.

Main Methods:

Analysis of cell-mediated immunity (CMI) data from 12,000 healthy individuals, cancer patients, and patients with precancerous cervical lesions.
Comparison of immune responses to specific cancer antigens and a non-specific lactate dehydrogenase-elevating (LDH) virus antigen.
Assessment of the impact of LDH virus RNA on the ratio of coherent/random oscillations in cellular electromagnetic fields.

Main Results:

Both specific cancer antigens and the non-specific LDH virus antigen elicited similar CMI responses across various patient groups.
The non-specific LDH virus antigen showed efficacy in all examined cancers, unlike specific antigens.
LDH virus RNA was found to reduce the ratio of coherent/random oscillations, decreasing the influence of the cellular electromagnetic field on DNA bonding.

Conclusions:

Parasitic virus energy consumption, leading to reduced coherent cellular electromagnetic fields, increases the probability of random genome reactions and cancer initiation.
The energy mechanism involving cellular electromagnetic fields and biochemical reaction rates provides a novel explanation for genome mutation.
CMI responses to cancer and LDH virus antigens support an energy-based mechanism in cancer development.