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The Prevalence of Celiac Disease in Children With Arterial Ischemic Stroke
1*Department of Pediatric Gastroenterology, Hepatology and Nutrition, Kecioren Research and Training Hospital †Department of Pediatric Neurology, Baskent University Faculty of Medicine, Ankara, Turkey.
Insights
Celiac disease (CD) is not more common in children with arterial ischemic stroke (AIS). Screening for CD is not routinely recommended for pediatric AIS, though recurrent cases may warrant investigation.
Area of Science:
- Pediatric Neurology
- Gastroenterology
- Immunology
Background:
- A rare association exists between celiac disease (CD) and arterial ischemic stroke (AIS) in both adults and children.
- The prevalence of CD in pediatric AIS populations requires further investigation.
Purpose of the Study:
- To determine the prevalence of celiac disease (CD) in children and adolescents diagnosed with arterial ischemic stroke (AIS).
Main Methods:
- Serum levels of tissue transglutaminase antibody immunoglobulin (Ig)A and total IgA were measured in 76 children with AIS and 102 healthy controls.
- Participants with positive tissue transglutaminase IgA antibody results underwent duodenal biopsy for confirmation.
Main Results:
- Two patients (2.26%) in the AIS group and two (1.96%) in the control group had positive tissue transglutaminase IgA antibodies (P=0.89).
- Celiac disease was confirmed by duodenal biopsy in only one patient within the AIS cohort.
- The prevalence of CD did not significantly differ between children with AIS and healthy controls.
Conclusions:
- Children experiencing acute arterial stroke (AIS) do not show a higher prevalence of celiac disease (CD) compared to healthy children.
- Routine screening for CD is not indicated in the management of pediatric AIS.
- Consideration for CD screening may be appropriate for pediatric patients with recurrent AIS.
Objective:
The association between arterial ischemic stroke (AIS) and celiac disease (CD) has been described in only a few cases in adults and children. We aim to determine the prevalence of CD in children and adolescents with AIS.
Study Design:
We investigated serum levels of tissue transglutaminase antibody immunoglobulin (Ig)A and total IgA from 76 children with AIS and in a healthy control group of 102 children. Study participants who were positive for tissue transglutaminase IgA antibodies underwent a duodenal biopsy.
Results:
A total of 2 patients in the AIS group (2.26%) and 2 in the control group (1.96%) had positive serum tissue transglutaminase antibody (P=0.89; 95% confidence interval, -5.05 to 6.89). Duodenal biopsy confirmed CD in only 1 patient who had AIS.
Conclusions:
In the present study, children with acute arterial stroke did not exhibit a higher prevalence rate of CD compared with healthy controls. Therefore, the screening test for CD is not a necessary part of the management of AIS in children. However, cases of recurrent AIS could be examined for CD.
