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Updated: Mar 16, 2026
Doppler Optical Coherence Tomography of Retinal Circulation
Published on: September 18, 2012
EARLY CRT MONITORING USING TIME-DOMAIN OPTICAL COHERENCE TOMOGRAPHY DOES NOT ADD TO VISUAL ACUITY FOR PREDICTING
Katy J L Bell1, Andrew Hayen, Paul Glasziou
1*Sydney School of Public Health, University of Sydney, Sydney, Australia; †Faculty of Health Sciences and Medicine, Bond University, Gold Coast, Australia; ‡School of Public Health and Community Medicine, University of New South Wales, Sydney, Australia; §Department of Health, Australian Government, Canberra, Australia; ¶Novartis Pharmaceuticals, Sydney, Australia; **Numerus Limited, Wokingham, United Kingdom; ††Numerus Limited, Tübingen, Germany; and ‡‡Westmead Institute, University of Sydney, Sydney, Australia.
Purpose:
Our primary purpose was to assess the clinical (predictive) validity of central retinal thickness (CRT) and best corrected visual acuity (BCVA) at 1 week and 1 month after starting treatment with ranibizumab for central retinal vein occlusion. The authors also assessed detectability of response to treatment.
Methods:
The authors used data from 325 participants in the CRUISE study, which included measurement of time-domain CRT and BCVA at baseline, 1 week, 1 month, and 6 months postrandomization. Analysis of covariance models were fitted to assess clinical validity, and distributions of change were constructed to assess detectability of response.
Results:
There was no evidence that 1-week CRT, and very strong evidence that 1-week BCVA were associated with baseline-adjusted BCVA at 6 months (P = 0.17 and P < 0.001, respectively). There was strong evidence that both 1-month CRT and 1-month BCVA were associated with baseline-adjusted 6-month BCVA (P = 0.005 and P < 0.001, respectively), but simultaneous adjustment found evidence of independent association only for BCVA (P = 0.71 and P < 0.001 for CRT and BCVA, respectively). Detectability of response tended to be higher for CRT than BCVA at 1 week and 1 month but by 6 months these were equivalent for CRT and BCVA.
Conclusion:
In this study, BCVA monitoring of treated central retinal vein occlusion patients seemed more informative than time-domain optical coherence tomography monitoring.
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