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Updated: Mar 16, 2026
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Screening Assays to Characterize Novel Endothelial Regulators Involved in the Inflammatory Response
Published on: September 15, 2017
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Targeting Inflammation in Primary Cardiovascular Prevention
Federico Carbone1, Luca Liberale, Aldo Bonaventura
1First Clinic of Internal Medicine, Department of Internal Medicine, University of Genoa, 6 viale Benedetto XV, 16132 Genoa, Italy.
Current Pharmaceutical Design
|August 24, 2016
Summary
Anti-inflammatory drugs show potential for cardiovascular disease prevention. However, clinical trial results are conflicting, highlighting the need for personalized patient selection and clearer inflammatory markers.
Area of Science:
- Cardiovascular pharmacotherapy
- Inflammation and cardiovascular disease
Background:
- Anti-inflammatory strategies are a growing trend in cardiovascular pharmacotherapy.
- Various drug classes show anti-inflammatory properties relevant to primary cardiovascular prevention.
- The impact of modifying inflammatory profiles on cardiovascular outcomes is still debated.
Purpose of the Study:
- To critically analyze randomized clinical trials of anti-inflammatory treatments for cardiovascular disease.
- To evaluate the potential benefits of these strategies in primary cardiovascular prevention.
Main Methods:
- Narrative review of randomized clinical trials.
- Focus on anti-inflammatory treatments targeting various inflammatory pathways.
Main Results:
- Early targets included tumor necrosis factor-α, interleukin-6, and interleukin-1 pathways.
- More recent strategies target lipoprotein-associated phospholipase A2, PCSK9, p38 MAPK, and NADPH oxidase.
- Clinical trials yielded conflicting results.
Conclusions:
- Patient inflammatory profiles need characterization to reduce study population heterogeneity.
- The utility of C-reactive protein (CRP) as a specific biomarker for atherosclerosis-related inflammation requires clarification.
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