Related Experiment Video
Updated: Mar 16, 2026
3D Whole-heart Myocardial Tissue Analysis
Published on: April 12, 2017
In vivo diffusion-tensor MRI of the human heart on a 3 tesla clinical scanner: An optimized second order (M2) motion
Christopher Nguyen1, Zhaoyang Fan1, Yibin Xie1
1Biomedical Imaging Research Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA.
Purpose:
To optimize a diffusion-prepared balanced steady-state free precession cardiac MRI (CMR) technique to perform diffusion-tensor CMR (DT-CMR) in humans on a 3 Tesla clinical scanner METHODS: A previously developed second order motion compensated (M2) diffusion-preparation scheme was significantly shortened (40%) yielding sufficient signal-to-noise ratio for DT-CMR imaging. In 20 healthy volunteers and 3 heart failure (HF) patients, DT-CMR was performed comparing no motion compensation (M0), first order motion compensation (M1), and the optimized M2. Mean diffusivity (MD), fractional anisotropy (FA), helix angle (HA), and HA transmural slope (HATS) were calculated. Reproducibility and success rate (SR) were investigated.
Results:
M2-derived left ventricular (LV) MD, FA, and HATS (1.4 ± 0.2 μm2 /ms, 0.28 ± 0.06, -1.0 ± 0.2 °/%trans) were significantly (P < 0.001) less than M1 (1.8 ± 0.3 μm2 /ms, 0.46 ± 0.14, -0.1 ± 0.3 °/%trans) and M0 (4.8 ± 1.0 μm2 /ms, 0.70 ± 0.14, 0.1 ± 0.3 °/%trans) indicating less motion corruption and yielding values more consistent with previous literature. M2-derived DT-CMR parameters had higher reproducible (ICC > 0.85) and SR (82%) than M1 (ICC = 0.20-0.85; SR = 37%) and M0 (ICC = 0.20-0.30; SR = 11%). M2 DT-CMR was able to yield HA maps with smooth transmural transition from endocardium to epicardium.
Conclusion:
The proposed M2 DT-CMR reproducibly yielded bulk motion robust estimations of mean LV MD, FA, HA, and HATS on a 3T clinical scanner. Magn Reson Med 76:1354-1363, 2016. © 2016 International Society for Magnetic Resonance in Medicine.
Related Concept Videos
01:24Magnetic Resonance Imaging
01:21Imaging Studies for Cardiovascular System IV: CMRI
01:27Imaging Studies IV: Magnetic Resonance Imaging
01:30Radiological Investigation II: MRI and Ventilation Perfusion Scan
Magnetic Resonance Imaging (MRI) and Ventilation Perfusion Scans are two radiological investigations that offer detailed diagnostic images of the body, particularly lung structures.
MRI
MRI uses magnetic fields and radiofrequency signals to distinguish between normal and abnormal tissues. This technology provides a more detailed diagnostic image than CT scans, enabling it to characterize pulmonary nodules, stage bronchogenic carcinoma, and evaluate inflammatory activity in...