A ratiometric fluorescent sensor for the mitochondrial copper pool
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Ratiometric Biosensors that Measure Mitochondrial Redox State and ATP in Living Yeast Cells
Published on: July 22, 2013
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Clara Shen1, Jacek L Kolanowski, Carmen M-N Tran
1School of Chemistry, The University of Sydney, NSW 2006, Australia. Elizabeth.new@sydney.edu.au.
Metallomics : Integrated Biometal Science
|August 24, 2016
Abstract:
Copper plays a key role in the modulation of cellular function, defence, and growth. Here we present InCCu1, a ratiometric fluorescent sensor for mitochondrial copper, which changes from red to blue emission in the presence of Cu(i). Employing this probe in microscopy and flow cytometry, we show that cisplatin-treated cells have an impaired ability to accumulate copper in the mitochondria.
