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Incidence, Survival and Prevalence Statistics of Classical Myeloproliferative Neoplasm in Korea

Yoojoo Lim1, Jeong Ok Lee1, Soo Mee Bang2

  • 1Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Korea.

Journal of Korean Medical Science
|August 24, 2016
PubMed

Insights

This study presents the first Korean nationwide statistics for myeloproliferative neoplasms (MPN), revealing increasing incidence and prevalence of polycythemia vera (PV), myelofibrosis (MF), and essential thrombocythemia (ET). MF showed the lowest survival rate.

Area of Science:

  • Hematology
  • Oncology
  • Epidemiology

Background:

  • Nationwide statistical data on classical myeloproliferative neoplasms (MPN) in Korea were previously unavailable.
  • Understanding the epidemiology of MPN is crucial for public health planning and resource allocation.

Purpose of the Study:

  • To analyze the incidence, survival rates, and treatment patterns of polycythemia vera (PV), primary myelofibrosis (MF), and essential thrombocythemia (ET) in Korea.
  • To establish the first comprehensive Korean nationwide statistics for MPN.

Main Methods:

  • Utilized the Korea National Cancer Incidence Database (KNCIDB) and Health Insurance Review and Assessment Service (HIRA) database.
  • Analyzed data from 2003 to 2011, covering 4,342 new MPN cases.
  • Calculated crude incidence rates, five-year relative survival rates, and treatment patterns.

Main Results:

  • Essential thrombocythemia (ET) was the most common MPN, followed by MF and PV.
  • Crude incidence rates for PV, MF, and ET increased from 2003-2011.
  • The five-year relative survival rate for all MPN was 89.3%, with MF having the lowest at 53.1%.
  • Hydroxyurea prescription rates were higher in patients over 60.

Conclusions:

  • This study provides the first Korean nationwide statistics for MPN, essential thrombocythemia (ET), polycythemia vera (PV), and primary myelofibrosis (MF).
  • Findings indicate increasing trends in MPN incidence and prevalence, with significant survival disparities among subtypes.
  • The data can inform international comparisons and guide clinical guidelines.

Keywords:
IncidenceKoreaMyeloproliferative NeoplasmPrevalenceSurvival

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