Related Experiment Video
Updated: Mar 16, 2026
06:55
Assessment of Maternal Vascular Remodeling During Pregnancy in the Mouse Uterus
Published on: December 5, 2015
14.3K
Maternal creatine in pregnancy: a retrospective cohort study
H Dickinson1,2, M Davies-Tuck3,4, S J Ellery3,4
1The Ritchie Centre, Hudson Institute of Medical Research, Clayton, Vic., Australia. hayley.dickinson@hudson.org.au.
BJOG : an International Journal of Obstetrics and Gynaecology
|August 24, 2016
Summary
Maternal creatine levels in plasma and urine are linked to factors like smoking, BMI, and asthma. Higher maternal urine creatine is associated with increased birth weight and length, indicating a connection to fetal growth.
Area of Science:
- Obstetrics and Gynecology
- Biochemistry
- Perinatal Medicine
Background:
- Maternal creatine concentrations are influenced by various physiological and lifestyle factors during pregnancy.
- Understanding these associations is crucial for monitoring maternal and fetal well-being.
Purpose of the Study:
- To quantify creatine levels in maternal plasma and urine throughout gestation.
- To investigate the relationship between maternal characteristics, diet, and creatine concentrations.
- To determine the association between maternal creatine levels and fetal growth parameters.
Main Methods:
- Retrospective cohort study involving 287 pregnant women.
- Collection of plasma and urine samples at multiple gestational points (13, 18, 30, 36 weeks).
- Enzymatic analysis for creatine measurement and linear mixed models for association analysis.
Main Results:
- Maternal smoking, BMI, asthma, and socioeconomic status showed positive associations with creatine levels; parity showed a negative association.
- Maternal urine creatine concentration positively correlated with birthweight centile and length.
- Adjusted analysis indicated that increased urinary creatine was linked to higher birthweight centile and length.
Conclusions:
- Maternal factors significantly influence plasma and urine creatine concentrations during pregnancy.
- Maternal creatine levels are associated with fetal growth outcomes, suggesting a role in fetal development.
More Related Videos
Related Concept Videos
01:25Drug Dosing in Renal Diseases: Measurement of Serum Creatinine Concentration and Clearance
326
In healthy individuals, serum creatinine levels remain stable due to a balance between its constant production—primarily from muscle metabolism—and renal excretion. Creatinine is freely filtered by the glomeruli, making it a valuable marker for estimating renal function. When the glomerular filtration rate (GFR) decreases, the kidneys can only eliminate less creatinine, causing serum levels to rise.Serum creatinine concentration is widely used to estimate creatinine clearance...
326
01:28Drug Dosing in Renal Diseases: Estimation of Glomerular Filtration Rate Based on Serum Creatinine Concentration
290
Glomerular filtration rate (GFR) can be estimated from serum creatinine using the modification of diet in renal disease (MDRD) formula or the chronic kidney disease–epidemiology collaboration (CKD–EPI) equation. Both methods are widely used in clinical practice to assess kidney function and guide treatment decisions.The MDRD equation does not require weight or height measurements and is normalized to the body surface area of 1.73 m², considered the average adult surface area.
290
01:30Acute Kidney Injury IV: Diagnostic Studies and Prevention
452
Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
452
01:17Factors Affecting Renal Clearance: Renal Impairment
538
Renal dysfunction significantly impairs the renal clearance of drugs, leading to potential complications in drug therapy. Renal failure, which can be caused by various factors, poses a significant challenge in the elimination of drugs from the body.
One condition associated with renal failure is uremia. Uremia is characterized by impaired glomerular filtration and fluid accumulation in the body. This condition hinders the renal clearance of drugs, resulting in drug accumulation and potential...
One condition associated with renal failure is uremia. Uremia is characterized by impaired glomerular filtration and fluid accumulation in the body. This condition hinders the renal clearance of drugs, resulting in drug accumulation and potential...
538
01:07Determination of Renal Drug Clearance: Graphical and Midpoint Methods
463
Renal clearance, a crucial parameter in pharmacokinetics, can be determined using two different methods: the graphical method and the midpoint method. These methods provide insights into the rate of drug excretion by the kidneys and aid in assessing renal function.
The graphical method involves plotting the rate of drug excretion in urine against the plasma drug concentration. By analyzing the graph, the clearance can be calculated and obtained. Drugs rapidly excreted by the kidneys exhibit a...
The graphical method involves plotting the rate of drug excretion in urine against the plasma drug concentration. By analyzing the graph, the clearance can be calculated and obtained. Drugs rapidly excreted by the kidneys exhibit a...
463