Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

A new method for relating behavior to neuronal activity in performing monkeys.

E B Montgomery1

  • 1Department of Neurology and Neurological Surgery, Washington University School of Medicine, St. Louis, MO 63110.

Journal of Neuroscience Methods
|June 1, 1989
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Modeling the motor striatum under Deep Brain Stimulation in normal and MPTP conditions.

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference·2010
Same author

Modeling the effects of Deep Brain Stimulation on sensorimotor cortex in normal and MPTP conditions.

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference·2010
Same author

A longitudinal study of neuropsychological change in individuals with Parkinson's disease.

International journal of geriatric psychiatry·2003
Same author

Deep brain stimulation in epilepsy.

Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society·2002
Same author

Performance on the PD test battery by relatives of patients with progressive supranuclear palsy.

Neurology·2001
Same author

Evaluation of surgery for Parkinson's disease: report of the Therapeutics and Technology Assessment Subcommittee of the American Academy of Neurology.

Neurology·2000

This study introduces a novel method for analyzing neuronal recordings in monkeys, aligning neural activity with inherent patterns rather than predefined behaviors. This approach enhances the accuracy of relating neural changes to specific behaviors and inferring physiological insights.

Area of Science:

  • Neuroscience
  • Computational Neuroscience
  • Primate Research

Background:

  • Current methods for analyzing neuronal recordings often rely on predefined behavioral events, potentially leading to inaccurate interpretations.
  • The relevance of specific behavioral events to neuronal activity cannot always be determined beforehand, introducing bias.

Purpose of the Study:

  • To develop and present a new analytical method for single neuronal recordings in behaving monkeys.
  • To overcome limitations of existing methods by aligning neural activity to intrinsic patterns, not a priori behavioral assumptions.
  • To enable more accurate inference of physiological conclusions by testing the relationship between neuronal activity and behavior.

Main Methods:

  • The novel method aligns neuronal activity (rasters and histograms) based on inherent patterns within the neural data itself.

Related Experiment Videos

  • It determines trial-by-trial variability in temporal latencies between neuronal activity changes and behavioral events.
  • The approach assumes minimal latency variability indicates the most relevant behavioral event.

    • Main Results:

    • The new method allows for unbiased alignment of neuronal activity to behavior.
    • It provides a quantitative measure of latency variability, facilitating robust testing of neural-behavior relationships.
    • The method is applicable to both neuronal and electromyographic (EMG) data analysis.

    Conclusions:

    • This novel analytical framework improves the interpretation of neuronal recordings in freely behaving subjects.
    • It reduces reliance on potentially flawed a priori behavioral assumptions, leading to more reliable physiological insights.
    • The method offers a versatile tool for neuroscience research, including the analysis of motor control and cognitive processes.