Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Gastrointestinal Motility Disorders01:20

Gastrointestinal Motility Disorders

1.5K
Gastrointestinal or GI motility disorders are characterized by irregular gastrointestinal tract movements, disrupting food transit from the mouth to the anus. They are caused by damage or dysfunction in gut muscles or nerves. These disorders can cause symptoms such as severe constipation, diarrhea, abdominal pain, and swallowing difficulties. Disorders can affect any segment of the GI tract and range widely in severity, from common conditions like GERD to life-threatening conditions like...
1.5K
Drug Dosing: Geriatric Patients01:15

Drug Dosing: Geriatric Patients

340
Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...
340
Drugs Affecting GI Tract Motility: Dopamine Receptor Antagonists01:28

Drugs Affecting GI Tract Motility: Dopamine Receptor Antagonists

1.6K
Prokinetic agents are specialized medications that stimulate gastrointestinal (GI) motility, promoting food movement through the GI tract. Dopamine, an inhibitory neurotransmitter, plays a significant role in this process, reducing GI motility and indirectly controlling the speed of digestion. Dopamine receptor antagonists, such as metoclopramide and domperidone, offer a unique advantage as prokinetic agents. By blocking the dopamine receptors, these drugs increase GI motility, improving food...
1.6K
Drugs Affecting GI Tract Motility: Other Laxatives01:20

Drugs Affecting GI Tract Motility: Other Laxatives

1.3K
Laxatives are primarily used to alleviate constipation, a common gastrointestinal disorder characterized by infrequent bowel movements and difficulty passing stools. They work by various mechanisms to increase the volume or frequency of bowel movements. The primary modes of action of laxatives include increasing stool bulk, softening the stool, stimulating intestinal motility, and osmotically drawing water into the intestines.
Osmotic or saline laxatives, like magnesium hydroxide or milk of...
1.3K
Drugs Affecting GI Tract Motility: Serotonin Receptor Agonists01:23

Drugs Affecting GI Tract Motility: Serotonin Receptor Agonists

1.2K
Serotonin, a crucial neurotransmitter synthesized by enterochromaffin cells, plays a cardinal role in regulating gastrointestinal (GI) motility. With over 90% of the body's total serotonin in the GI tract, its influence on digestive processes is profound. Serotonin is swiftly released upon various stimuli, such as food boluses or certain drugs, triggering intrinsic sensory neurons in the myenteric plexus and extrinsic vagal and spinal sensory neurons. This leads to the activation of the...
1.2K
Pharmacodynamics in Geriatric Patients: Effects of Age01:27

Pharmacodynamics in Geriatric Patients: Effects of Age

308
Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
308

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

An International Multicenter Study of Native and Immigrant South Asian Crohn's Disease.

Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association·2025
Same author

Gene Expression in Barrett's Esophagus Cell Lines Resemble Esophageal Squamous Cell Carcinoma Instead of Esophageal Adenocarcinoma.

Cancers·2021
Same author

DNA methylation markers in esophageal cancer: an emerging tool for cancer surveillance and treatment.

American journal of cancer research·2021
Same author

Barrett's Epithelium to Esophageal Adenocarcinoma: Is There a "Point of No Return"?

Frontiers in genetics·2021
Same author

Recurring Translocations in Barrett's Esophageal Adenocarcinoma.

Frontiers in genetics·2021
Same author

Effect of Long-Term Mesalamine Therapy on Cancer-Associated Gene Expression in Colonic Mucosa of Patients with Ulcerative Colitis.

Digestive diseases and sciences·2018

Related Experiment Video

Updated: Mar 16, 2026

Assessing Gastrointestinal Motility in Caenorhabditis elegans RAC1/CED-10 Mutants as a Tool to Study Early Parkinson's Disease
05:17

Assessing Gastrointestinal Motility in Caenorhabditis elegans RAC1/CED-10 Mutants as a Tool to Study Early Parkinson's Disease

Published on: November 28, 2025

439

Gastrointestinal Dysmotility in the Elderly.

Neelam G Gidwaney1, Manisha Bajpai, Sita S Chokhavatia

  • 1Rutgers-Robert Wood Johnson Medical School, New Brunswick, NJ.

Journal of Clinical Gastroenterology
|August 24, 2016
PubMed
Summary

Digestive problems in older adults are often due to other health conditions and medications, not aging itself. A team approach and careful evaluation are key to improving quality of life.

More Related Videos

Author Spotlight: Reliable and Reproducible In Vitro Assessment of Drug Impact on Rat Intestinal Tubes
06:01

Author Spotlight: Reliable and Reproducible In Vitro Assessment of Drug Impact on Rat Intestinal Tubes

Published on: July 26, 2024

1.1K
Gastrointestinal Motility Monitor GIMM
08:15

Gastrointestinal Motility Monitor GIMM

Published on: December 1, 2010

31.6K

Related Experiment Videos

Last Updated: Mar 16, 2026

Assessing Gastrointestinal Motility in Caenorhabditis elegans RAC1/CED-10 Mutants as a Tool to Study Early Parkinson's Disease
05:17

Assessing Gastrointestinal Motility in Caenorhabditis elegans RAC1/CED-10 Mutants as a Tool to Study Early Parkinson's Disease

Published on: November 28, 2025

439
Author Spotlight: Reliable and Reproducible In Vitro Assessment of Drug Impact on Rat Intestinal Tubes
06:01

Author Spotlight: Reliable and Reproducible In Vitro Assessment of Drug Impact on Rat Intestinal Tubes

Published on: July 26, 2024

1.1K
Gastrointestinal Motility Monitor GIMM
08:15

Gastrointestinal Motility Monitor GIMM

Published on: December 1, 2010

31.6K

Area of Science:

  • Gerontology
  • Gastroenterology
  • Internal Medicine

Background:

  • The global population of individuals aged 60 and above has tripled since 1950.
  • Aging itself has minimal direct impact on the gastrointestinal (GI) system.
  • Digestive dysfunctions in older adults are frequently linked to comorbid conditions and their pharmacological treatments.

Purpose of the Study:

  • To review age-related changes in GI motility.
  • To outline the clinical presentation of GI dysmotility in the elderly.
  • To discuss therapeutic principles for symptomatic older patients with GI dysmotility.

Main Methods:

  • Multidisciplinary assessment involving geriatricians, gastroenterologists, neurologists, speech pathologists, and physical therapists.
  • Consideration of radiographic and endoscopic evaluations, weighing risks and benefits.
  • Focus on improving health-related quality of life when cure is not feasible.

Main Results:

  • Comorbidities and polypharmacy are primary drivers of digestive dysfunction in the aging population.
  • Comprehensive functional and neurological assessments are crucial for older patients.
  • Treatment strategies prioritize quality of life and symptom management.

Conclusions:

  • Digestive dysfunction in older adults necessitates a holistic, multidisciplinary approach.
  • Preventive strategies include promoting healthy aging, managing comorbidities, and minimizing polypharmacy.
  • Effective management focuses on functional assessment and tailored therapeutic interventions to enhance patient well-being.