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Updated: Mar 16, 2026
Author Spotlight: Investigating the Mechanisms and Inducing Models of Polycystic Ovary Syndrome
Published on: July 5, 2024
The miR-449b polymorphism, rs10061133 A>G, is associated with premature ovarian insufficiency
Hong Pan1, Beili Chen, Jing Wang
11Center for Reproductive Medicine, Department of Obstetrics and Gynecology, The First Affiliated Hospital of Anhui Medical University, Hefei, China2National Research Institute for Family Planning, Beijing, China3College of Basic Medicine, Capital University of Medical Sciences, Beijing, China.
Objective:
To determine if the miR-449b polymorphism, rs10061133 A>G, is associated with premature ovarian insufficiency (POI) pathogenesis.
Methods:
From January 2011 to December 2014, a total of 148 individuals with POI and 225 age-matched controls were collected from the Center for Reproductive Medicine, 1st Affiliated Hospital of Anhui Medical University (Hefei, China). Genotyping of miR-449b rs1006113 was performed using matrix-assisted laser desorption ionization time-of-flight-based mass spectrometry.
Results:
Rs10061133 A>G is a highly conserved SNP locus in the mature area of miR-449b. Association analysis shows that the rs10061133 AA genotype is a risk factor for POI.
Conclusions:
Our study provides the first evidence that the miR-449b rs10061133 AA genotype is associated with POI risk.
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