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Catheter-Directed Thrombolysis via Small Saphenous Veins for Treating Acute Deep Venous Thrombosis

Bin Yang1, Xiao-Dong Xu2, Peng Gao1

  • 1Department of Vascular Surgery, Jining First People's Hospital, Jining, Shandong, China (mainland).

Medical Science Monitor : International Medical Journal of Experimental and Clinical Research
|August 24, 2016
PubMed

Insights

Catheter-directed thrombolysis via the small saphenous vein is more effective and safer than systemic thrombolysis for acute deep vein thrombosis, significantly reducing post-thrombotic syndrome. This treatment offers a viable option for DVT patients.

Area of Science:

  • Vascular Surgery
  • Interventional Radiology
  • Thrombosis Management

Background:

  • Limited comparative data exists for catheter-directed thrombolysis (CDT) via small saphenous veins versus systemic thrombolysis in acute deep venous thrombosis (DVT).
  • Evaluating the efficacy and safety of these DVT treatment modalities is crucial for clinical decision-making.

Purpose of the Study:

  • To compare the efficacy and safety of CDT via the small saphenous veins against systemic thrombolysis for acute DVT patients.
  • To assess thrombolysis efficiency, limb circumference changes, and post-thrombotic syndrome (PTS) incidence.

Main Methods:

  • A comparative study involving 66 acute DVT patients from June 2012 to December 2013.
  • Patients were divided into two groups: systemic thrombolysis (ST group, n=27) and CDT via small saphenous veins (CDT group, n=39).
  • Thrombolysis efficiency, limb circumference, and PTS rates were recorded and analyzed.

Main Results:

  • CDT demonstrated significantly higher thrombolysis efficiency (71.26%) compared to ST (48.26%, P=0.001).
  • While limb circumferences increased post-procedure in both groups, the CDT group showed significantly greater reduction on days 7 and 14 (P<0.05).
  • The incidence of post-thrombotic syndrome was significantly lower in the CDT group (17.9%) versus the ST group (51.85%, P=0.007).

Conclusions:

  • Catheter-directed thrombolysis via the small saphenous veins is an effective and safe treatment for acute deep venous thrombosis.
  • This approach offers a feasible alternative with improved outcomes regarding PTS compared to systemic thrombolysis.

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