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Related Concept Videos

Reticular Dermis01:15

Reticular Dermis

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The papillary and reticular dermis are the two layers of the dermis. They are made of connective tissue with fibers of collagen extending from one to the other, making the border between the two somewhat indistinct. The dermal papillae extending into the epidermis belong to the papillary layer, whereas the dense collagen fiber bundles below belong to the reticular layer.
Reticular Layer
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Unlike epithelial tissue, which is composed of cells closely packed with little or no extracellular space in between, connective tissue cells are dispersed in a matrix. This extracellular matrix (ECM) is composed of fibrous proteins like collagen, elastin, and fibronectin in a ground substance consisting of interstitial fluid, cell adhesion proteins, and proteoglycans. The proteoglycans form a gel-like material in the spaces between cells and provide hydration, buffering, binding, and force...
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The Extracellular Matrix01:29

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In order to maintain tissue organization, many animal cells are surrounded by structural molecules that make up the extracellular matrix (ECM). Together, the molecules in the ECM maintain the structural integrity of tissue as well as the remarkable specific properties of certain tissues.
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Arthroscopic Biologic Tuberoplasty With a Dermal Allograft Leads to Significant Improvement in Functional Outcomes in Patients With Massive, Irreparable Rotator Cuff Tears.

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Related Experiment Video

Updated: Mar 16, 2026

Anterior Capsular Reconstruction with Human Dermal Allograft for Irreparable Subscapularis Tears
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Anterior Capsular Reconstruction with Human Dermal Allograft for Irreparable Subscapularis Tears

Published on: May 9, 2025

592

Acellular Dermal Matrix in Rotator Cuff Surgery.

Joseph Cooper, Raffy Mirzayan1

  • 1Department of Orthopaedic Surgery, Kaiser Permanente, Baldwin Park, CA. raffy.x.mirzayan@kp.org.

American Journal of Orthopedics (Belle Mead, N.J.)
|August 24, 2016
PubMed
Summary

Rotator cuff repair (RCR) surgery often succeeds clinically but fails structurally, with high re-tear rates. Augmenting RCR with acellular dermal matrices may strengthen repairs and reduce failures.

Area of Science:

  • Orthopedic Surgery
  • Biomaterials Science
  • Musculoskeletal Research

Background:

  • Rotator cuff repair (RCR) success is assessed clinically and structurally.
  • While clinical outcomes are generally positive, high structural failure rates (re-tears) are a significant concern.
  • Factors like tendon quality, patient age, smoking, and fatty infiltration contribute to RCR failure.

Purpose of the Study:

  • To review the literature on rotator cuff repair (RCR) outcomes.
  • To investigate the potential of acellular dermal matrices (ADMs) for augmenting RCR.
  • To determine if ADM augmentation can reduce re-tear rates by strengthening the suture-tendon interface.

Main Methods:

  • Systematic review of published literature on rotator cuff repair (RCR).

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Modified Long Head of Biceps Tendon Rerouting and Fixation as Partial Capsular Reconstruction for Massive Irreparable Rotator Cuff Tears
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Arthroscopic Management of Massive Irreparable Rotator Cuff Tears: Whole Rotator Cable Reconstruction Using Proximal Biceps Tendon Autograft
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Modified Long Head of Biceps Tendon Rerouting and Fixation as Partial Capsular Reconstruction for Massive Irreparable Rotator Cuff Tears

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  • Analysis of studies examining factors influencing RCR structural integrity.
  • Evaluation of research on acellular dermal matrices (ADMs) as augmentation in RCR.

    • Main Results:

    • Rotator cuff repair (RCR) structural integrity is often compromised at the suture-tendon interface.
    • Suture pullout is a common failure mechanism in RCR.
    • Evidence supporting ADM augmentation to improve RCR structural integrity is being reviewed.

    Conclusions:

    • The suture-tendon interface is a critical weakness in rotator cuff repair (RCR).
    • Acellular dermal matrices (ADMs) show potential for augmenting RCR to enhance structural integrity.
    • Further research is needed to confirm if ADM augmentation effectively reduces re-tear rates in RCR.