Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

The Nucleolus02:55

The Nucleolus

10.6K
The nucleolus is the most prominent substructure of the nucleus. When it was first discovered, it was considered to be an isolated organelle that forms fibrils and granules. In 1931, the relationship between the nucleolus and chromosomes was first described by Heitz. He observed that the appearance and size of nucleolus varies depending on the stage of the cell cycle. He also noticed constricted regions on different chromosomes clustered together at definite cell cycle stages. These regions,...
10.6K
Biosynthesis of Nucleic Acids01:28

Biosynthesis of Nucleic Acids

1.4K
Nucleic acid biosynthesis is a fundamental biochemical process that produces the purine and pyrimidine nucleotides essential for DNA and RNA synthesis. This pathway maintains a balanced nucleotide pool, preventing imbalances that could jeopardize genetic integrity and cellular function. Given the crucial role of nucleotides, their synthesis is tightly regulated to ensure proper cellular homeostasis.Purine BiosynthesisThe biosynthesis of purine nucleotides begins with ribose-5-phosphate, a...
1.4K
Nucleosome Remodeling02:54

Nucleosome Remodeling

11.5K
Nucleosomes are the basic units of chromatin compaction. Each nucleosome consists of the DNA bound tightly around a histone core, which makes the DNA inaccessible to DNA binding proteins such as DNA polymerase and RNA polymerase. Hence, the fundamental problem is to ensure access to DNA when appropriate, despite the compact and protective chromatin structure.
Nucleosome remodeling complex
Eukaryotic cells have specialized enzymes called ATP-dependent nucleosome remodeling enzymes. These enzymes...
11.5K
Nucleotide Excision Repair01:08

Nucleotide Excision Repair

41.6K
Overview
41.6K
Nucleotide Excision Repair01:38

Nucleotide Excision Repair

5.6K
DNA Distortion and Damage
Cells are regularly exposed to mutagens—factors in the environment that can damage DNA and generate mutations. UV radiation is one of the most common mutagens and is estimated to introduce a significant number of changes in DNA. These include bends or kinks in the structure, which can block DNA replication or transcription. If these errors are not fixed, the damage can cause mutations, which in turn can result in cancer or disease depending on which sequences are...
5.6K
Abnormal Proliferation02:23

Abnormal Proliferation

5.4K
Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
5.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Synthesis and in vivo evaluation of a bifunctional, glutamic acid derived chelator for the <sup>203/212</sup>Pb theranostic pair.

EJNMMI radiopharmacy and chemistry·2026
Same author

Early Detriment Analysis of First-Line Nivolumab plus Ipilimumab-Based Therapy in Patients with Metastatic Non-Small Cell Lung Cancer.

Clinical cancer research : an official journal of the American Association for Cancer Research·2026
Same author

An analysis of succinate dehydrogenase B in pleural mesothelioma.

Discover oncology·2026
Same author

Dissecting non-small cell lung cancer (NSCLC) with blood proteomics-from surgical to immunotherapeutic responses.

NPJ precision oncology·2026
Same author

FKBP52 in cancer biology and therapy: molecular mechanisms, signalling networks, and drug targeting of the FKBP protein family.

Biochemical pharmacology·2026
Same author

Steroidal-nitroxide hybrid sustains oxidative stress and enhances cisplatin efficacy in vitro across multiple cancer cell lines.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie·2026
Same journal

PSMD1 and PSMD2 regulate HepG2 cell proliferation and apoptosis via modulating cellular lipid droplet metabolism.

BMC molecular biology·2019
Same journal

The effect of BACE1-AS on β-amyloid generation by regulating BACE1 mRNA expression.

BMC molecular biology·2019
Same journal

Overlapping transcriptional expression response of wheat zinc-induced facilitator-like transporters emphasize important role during Fe and Zn stress.

BMC molecular biology·2019
Same journal

MiR-32-5p influences high glucose-induced cardiac fibroblast proliferation and phenotypic alteration by inhibiting DUSP1.

BMC molecular biology·2019
Same journal

Comparison of miRNA-101a-3p and miRNA-144a-3p regulation with the key genes of alpaca melanocyte pigmentation.

BMC molecular biology·2019
Same journal

Correction to: A protocol for custom CRISPR Cas9 donor vector construction to truncate genes in mammalian cells using pcDNA3 backbone.

BMC molecular biology·2019
See all related articles

Related Experiment Video

Updated: Mar 16, 2026

Identification of Nucleolar Factors During HIV-1 Replication Through Rev Immunoprecipitation and Mass Spectrometry
09:38

Identification of Nucleolar Factors During HIV-1 Replication Through Rev Immunoprecipitation and Mass Spectrometry

Published on: June 26, 2019

8.7K

Nucleophosmin: from structure and function to disease development.

Joseph K Box1, Nicolas Paquet2, Mark N Adams1

  • 1School of Biomedical Research, Institute of Health and Biomedical Innovation at the Translational Research Institute, Queensland University of Technology, Brisbane, QLD, Australia.

BMC Molecular Biology
|August 25, 2016
PubMed
Summary
This summary is machine-generated.

Nucleophosmin (NPM1) is vital for cell functions and DNA repair. NPM1 mutations are linked to cancer, highlighting its complex role as both a proto-oncogene and tumor suppressor.

Keywords:
ApoptosisCancerDNA repairNucleophosmin 1

More Related Videos

Efficient Gene Knockdown in the Liver via Intrasplenic Injection of Adeno-Associated Virus Serotype 8 (AAV8)-Delivered Small Hairpin RNA
04:29

Efficient Gene Knockdown in the Liver via Intrasplenic Injection of Adeno-Associated Virus Serotype 8 (AAV8)-Delivered Small Hairpin RNA

Published on: November 1, 2024

1.1K
Assay to Measure Nucleocytoplasmic Transport in Real Time within Motor Neuron-like NSC-34 Cells
08:53

Assay to Measure Nucleocytoplasmic Transport in Real Time within Motor Neuron-like NSC-34 Cells

Published on: May 16, 2017

9.2K

Related Experiment Videos

Last Updated: Mar 16, 2026

Identification of Nucleolar Factors During HIV-1 Replication Through Rev Immunoprecipitation and Mass Spectrometry
09:38

Identification of Nucleolar Factors During HIV-1 Replication Through Rev Immunoprecipitation and Mass Spectrometry

Published on: June 26, 2019

8.7K
Efficient Gene Knockdown in the Liver via Intrasplenic Injection of Adeno-Associated Virus Serotype 8 (AAV8)-Delivered Small Hairpin RNA
04:29

Efficient Gene Knockdown in the Liver via Intrasplenic Injection of Adeno-Associated Virus Serotype 8 (AAV8)-Delivered Small Hairpin RNA

Published on: November 1, 2024

1.1K
Assay to Measure Nucleocytoplasmic Transport in Real Time within Motor Neuron-like NSC-34 Cells
08:53

Assay to Measure Nucleocytoplasmic Transport in Real Time within Motor Neuron-like NSC-34 Cells

Published on: May 16, 2017

9.2K

Area of Science:

  • Molecular Biology
  • Cancer Biology
  • Genetics

Background:

  • Nucleophosmin (NPM1) is a crucial cellular protein involved in mRNA transport, chromatin remodeling, apoptosis, and genome stability.
  • NPM1's diverse functions are critical for normal cellular processes, and its dysregulation (overexpression, mutation, rearrangement, deletion) is common in cancer.

Purpose of the Study:

  • To review the less-understood role of NPM1 in DNA repair pathways.
  • To examine NPM1's regulation of apoptosis.
  • To discuss the significance of NPM1 mutations in various cancers.

Main Methods:

  • Literature review of existing research on NPM1.
  • Analysis of NPM1's involvement in DNA repair mechanisms.
  • Examination of NPM1's role in apoptotic pathways.
  • Review of NPM1 mutation data in cancer studies.

Main Results:

  • NPM1 plays a significant role in maintaining genome stability through its involvement in DNA repair.
  • NPM1 influences apoptosis, acting as both a potential proto-oncogene and a tumor suppressor depending on context.
  • Specific NPM1 mutations are frequently observed in certain types of cancer, impacting disease progression.

Conclusions:

  • NPM1 is a multifunctional protein with critical roles in DNA repair and apoptosis.
  • Understanding NPM1's dual role in cancer is essential for developing targeted therapies.
  • Further research into NPM1's DNA repair functions could reveal new therapeutic strategies for cancer treatment.