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Updated: Mar 16, 2026

Protocol for the Synthesis of Ortho-trifluoromethoxylated Aniline Derivatives
Published on: January 19, 2016
Facile Preparation of Flavinium Organocatalysts
Yukihiro Arakawa1, Takahiro Oonishi1, Takahiro Kohda1
1Department of Applied Chemistry, Tokushima University, Minamijosanjima, Tokushima, 770-8506, Japan.
Abstract:
We developed a safe, simple, inexpensive, and environmentally benign method for preparing N(5)-ethylated flavinium organocatalysts without using hazardous reagents or inert conditions as previously required. 5-Ethyl-3-methyllumiflavinium cation was prepared from its reduced form by NaNO2 -free aerobic oxidation, which was subsequently extracted onto commercial cation-exchange resins under NaClO4 -free conditions. The resulting resin-immobilized flavinium salts were found to be effective organocatalysts for aerobic oxidation reactions.
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