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4α-Methylated steroids with cytotoxic activity from the soft coral Litophyton mollis
Marijana Zovko Končić1, Efstathia Ioannou2, Wamtinga Richard Sawadogo3
1Department of Pharmacognosy and Chemistry of Natural Products, Faculty of Pharmacy, National and Kapodistrian University of Athens, Panepistimiopolis Zografou, Athens 15771, Greece; Faculty of Pharmacy and Biochemistry, University of Zagreb, Zagreb 10000, Croatia.
Abstract:
Seven new (1-3, 5 and 8-10) and three previously reported (4, 6 and 7) 4α-methylated steroids were isolated from the organic extract of the gorgonian Litophyton mollis. The structures and the relative configurations of the isolated natural products were determined on the basis of extensive analyses of their NMR and MS data. Metabolites 1 and 5-8 exhibited cytotoxic activity against K562 human chronic myelogenous leukemia cells with IC50 values below 10μM, while at the same time displaying low toxicity against healthy PBMCs.