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Area of Science:

  • Analytical Chemistry
  • Mass Spectrometry
  • Plasma Physics

Background:

  • Ambient mass spectrometry requires efficient ionization methods.
  • Existing methods can suffer from electrode degradation and chemical interferences.
  • Direct sampling techniques are desirable for simplified workflows.

Purpose of the Study:

  • To present a novel direct sampling ionization scheme for ambient mass spectrometry.
  • To demonstrate an electrode-free laser-induced plasma ionization source.
  • To evaluate its applicability for analyzing diverse analytes in complex matrices.

Main Methods:

  • Utilizing a quasi-continuous laser-induced plasma in ambient air for desorption and ionization.
  • Employing an indirect ionization mechanism via interaction with plasma-generated species.
  • Leveraging collisional cooling by ambient air to stabilize ions.

Main Results:

  • The developed method is electrode-free, avoiding chemical interferences and electrode consumption.
  • The plasma's electro-neutrality minimizes charge effects and trajectory drift.
  • Analysis of various analytes (hydrocarbons, sugars, pharmaceuticals, biomolecules) yielded meaningful spectra with minimal fragmentation.
  • The indirect ionization scheme proved widely unspecific to analyte chemistry.

Conclusions:

  • The novel laser-induced plasma ionization scheme is a robust and versatile tool for ambient mass spectrometry.
  • Its electrode-free design and indirect ionization mechanism offer significant advantages over traditional methods.
  • The technique shows promise for rapid analysis of complex samples without extensive preparation.