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Association between hyperglycaemic crisis and long-term major adverse cardiovascular events: a nationwide

Li-Hsin Chang1, Liang-Yu Lin2, Ming-Tsun Tsai3

  • 1Division of Endocrinology and Metabolism, Department of Internal Medicine, Taipei Veterans General Hospital, Taoyuan Branch, Taoyuan, Taiwan School of Medicine, National Yang-Ming University, Taipei, Taiwan.

BMJ Open
|August 25, 2016
PubMed

Insights

Diabetic patients experiencing hyperglycaemic crisis face increased long-term cardiovascular risks, particularly younger individuals. This highlights the need for proactive management and further research into these adverse outcomes.

Area of Science:

  • Cardiology
  • Endocrinology
  • Public Health

Background:

  • Hyperglycaemic crisis is linked to significant in-hospital complications.
  • Long-term cardiovascular consequences of hyperglycaemic crisis remain under-investigated.

Purpose of the Study:

  • To investigate the association between hyperglycaemic crisis and subsequent major adverse cardiovascular events (MACEs).

Main Methods:

  • Population-based cohort study using Taiwan's National Health Insurance Research Database (1996-2012).
  • 2171 diabetic patients with hyperglycaemic crisis were propensity score-matched with 8684 diabetic patients without the crisis.
  • Comparison of long-term MACEs risk between the two cohorts.

Main Results:

  • Patients with hyperglycaemic crisis had a higher incidence of MACEs (31.1% vs 24.1%).
  • Hyperglycaemic crisis significantly increased the risk of long-term MACEs (adjusted HR=1.76).
  • Acute myocardial infarction and congestive heart failure were the most affected MACEs; younger patients faced higher risks.

Conclusions:

  • Hyperglycaemic crisis is a significant risk factor for long-term MACEs, especially in younger diabetic patients.
  • Further prospective studies are recommended to validate these findings.
Abstract

Keywords:
diabetic ketoacidosishyperglycemic crisishyperglycemic hyperosmolar statusmajor adverse cardiovascular event

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