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Related Experiment Video

Updated: Mar 16, 2026

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Variable disruption of a syntactic processing network in primary progressive aphasia.

Stephen M Wilson1,2,3, Andrew T DeMarco1, Maya L Henry4,5

  • 1Department of Speech, Language, and Hearing Sciences, University of Arizona, Tucson, AZ, USA.

Brain : a Journal of Neurology
|August 25, 2016
PubMed
Summary

Syntactic comprehension deficits in primary progressive aphasia involve more than just frontal lobe damage. Functional disruption of a broader brain network, including temporal and parietal regions, also contributes to impaired syntax processing.

Keywords:
functional MRIprimary progressive aphasiareaction timesyntaxvoxel-based morphometry

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Area of Science:

  • Neuroscience
  • Neurology
  • Cognitive Science

Background:

  • Syntactic processing deficits in primary progressive aphasia (PPA) show significant individual variability.
  • Left inferior frontal cortex damage is often linked to these deficits, but other studies suggest a broader syntactic network.

Purpose of the Study:

  • To investigate the functional neuroanatomy of syntactic comprehension in PPA.
  • To reconcile differing findings on the brain regions involved in syntactic processing.

Main Methods:

  • Functional magnetic resonance imaging (fMRI) was used in 51 individuals with PPA.
  • Trial-by-trial reaction time served as a proxy for syntactic processing load.
  • Relationships between functional abnormalities and cortical atrophy were examined.

Main Results:

  • Left frontal atrophy predicted syntactic comprehension impairment.
  • Functional disruption in a broader network (posterior frontal, posterior temporal, intraparietal sulcus) was observed.
  • This network was modulated by syntax in healthy controls and less so in PPA patients with impaired syntax.

Conclusions:

  • Syntactic deficits in PPA result from both left frontal changes and disruption of a wider syntactic processing network.
  • Understanding this network is crucial for comprehending PPA-related language impairments.
  • The findings highlight the distributed nature of syntactic processing in the brain.