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Published on: April 28, 2016
Effect of ghrelin on regulation of splenic sympathetic nerve discharge
Sivasai Balivada1, Hitesh N Pawar1, Shawnee Montgomery2
1Department of Anatomy and Physiology, Kansas State University, Manhattan, KS 66506, United States; Department of Biological Sciences, College of Science, University of Texas at El Paso, El Paso, TX 79968, United States.
Abstract:
Ghrelin influences immune system function and modulates the sympathetic nervous system; however, the contribution of ghrelin to neural-immune interactions is not well-established because the effect of ghrelin on splenic sympathetic nerve discharge (SND) is not known. This study tested the hypothesis that central ghrelin administration would inhibit splenic SND in anesthetized rats. Rats received intracerebroventricular (ICV) injections of ghrelin (1nmol/kg) or aCSF. Lumbar SND recordings provided a non-visceral nerve control. The ICV ghrelin administration significantly increased splenic and lumbar SND, whereas mean arterial pressure (MAP) was not altered. These findings provide fundamental information regarding the nature of sympathetic-immune interactions.
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