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Updated: Mar 16, 2026

Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice
Published on: June 8, 2022
Antiphospholipid syndrome and kidney disease
Frank Bienaimé1, Christophe Legendre2, Fabiola Terzi3
1Université Paris Descartes, Sorbonne Paris Cité, Hôpital Necker-Enfants Malades, Paris, France; Service d'Explorations Fonctionnelles, Hôpital Necker-Enfants Malades, Paris, France; INSERM U1151, Institut Necker Enfants Malades, Hôpital Necker-Enfants Malades, Paris, France.
Antiphospholipid syndrome (APS) causes autoimmune disease and thrombosis. APS can lead to kidney damage, including antiphospholipid nephropathy, with limited understanding of isolated cases and future treatment potential.
Area of Science:
- Nephrology
- Immunology
- Vascular Biology
Background:
- Antiphospholipid syndrome (APS) is an autoimmune disorder linked to pathogenic antiphospholipid antibodies.
- APS commonly causes recurrent thrombosis and obstetrical complications.
- Renal manifestations of APS include thrombosis, stenosis, and antiphospholipid nephropathy.
Purpose of the Study:
- To review the renal manifestations of antiphospholipid syndrome.
- To discuss the clinical significance and management of antiphospholipid nephropathy.
- To explore emerging therapeutic avenues for APS-related kidney disease.
Main Methods:
- Literature review of antiphospholipid syndrome and renal complications.
- Analysis of intrarenal lesions and their association with APS.
- Discussion of current evidence guiding management strategies.
Main Results:
- Antiphospholipid nephropathy involves thrombotic microangiopathy, vascular lesions, and ischemia.
- The impact of APS on kidney function can range from mild to acute renal failure.
- The significance of isolated antiphospholipid nephropathy is not fully understood.
Conclusions:
- APS significantly impacts renal health, particularly in lupus and post-transplant settings.
- Limited evidence exists for managing APS-related renal complications.
- Understanding molecular mechanisms offers potential for targeted therapies and monitoring.
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