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Levels of betatrophin decrease during pregnancy despite increased insulin resistance, beta-cell function and

A Zielińska1, R Maciulewski1, K Siewko1

  • 1Department of Endocrinology, Diabetology and Internal Medicine, Medical University of Bialystok, Bialystok, Poland.

Diabetes & Metabolism
|August 25, 2016
PubMed
Summary
This summary is machine-generated.

Betatrophin levels decrease during pregnancy, indicating it does not significantly contribute to insulin resistance (IR) or beta-cell expansion in healthy women. This contrasts with findings in diabetes and obesity.

Keywords:
BetatrophinInsulin resistancePregnancy

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Area of Science:

  • Endocrinology
  • Metabolic Health
  • Reproductive Physiology

Background:

  • Betatrophin is implicated in insulin resistance (IR), with elevated levels observed in type 2 diabetes, obesity, and gestational diabetes.
  • Understanding betatrophin's role in pregnancy is crucial given its association with metabolic disorders.

Purpose of the Study:

  • To investigate the role of betatrophin in insulin resistance (IR).
  • To evaluate betatrophin's involvement in beta-cell proliferation during pregnancy in healthy women.

Main Methods:

  • Studied 80 healthy pregnant women across three trimesters and 45 at 3 months postpartum.
  • Included 30 non-pregnant healthy women as controls.
  • Measured betatrophin, glucose, insulin, C-peptide, and HbA1c; calculated HOMA-IR and HOMA-β scores.

Main Results:

  • Betatrophin concentrations were highest in the first trimester, decreasing significantly through pregnancy and returning to non-pregnant levels postpartum.
  • Insulin resistance (IR) and beta-cell function (HOMA-β) scores increased during gestation, peaking in the third trimester.
  • Postpartum, IR and beta-cell function returned to levels comparable to healthy non-pregnant women.

Conclusions:

  • Betatrophin concentrations decline during pregnancy.
  • The study suggests betatrophin does not play a significant role in the physiological expansion of beta-cell mass or the development of insulin resistance during pregnancy in healthy women.