Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Theories of Dissolution: The Danckwerts' Model and Interfacial Barrier Model01:09

Theories of Dissolution: The Danckwerts' Model and Interfacial Barrier Model

894
Various dissolution theories provide insight into the factors that influence the dissolution rate. Danckwerts' Model suggests that turbulence, rather than a stagnant layer, characterizes the dissolution medium at the solid-liquid interface. In this model, the agitated solvent contains macroscopic packets that move to the interface via eddy currents, facilitating the absorption and delivery of the drug to the bulk solution. The regular replenishment of solvent packets maintains the...
894
Protein Diffusion in the Membrane01:24

Protein Diffusion in the Membrane

6.1K
Proteins show rotational as well as lateral diffusion across the membrane. The lateral diffusion of proteins was confirmed through the cell fusion experiment where mouse and human cells were fused, resulting in hybrid cells. When the human and mouse cells fused, the specific membrane proteins on human and mouse cells were marked with the red and green-fluorescent markers, respectively. Initially, the red and green fluorescence was located on the respective hemisphere of the cell. As time...
6.1K
Intermolecular Forces03:13

Intermolecular Forces

76.0K
Atoms and molecules interact through bonds (or forces): intramolecular and intermolecular. The forces are electrostatic as they arise from interactions (attractive or repulsive) between charged species (permanent, partial, or temporary charges) and exist with varying strengths between ions, polar, nonpolar, and neutral molecules. The different types of intermolecular forces are ion–dipole, dipole–dipole, hydrogen bonds, and dispersion; among these, dipole–dipole, hydrogen...
76.0K
Intermolecular Forces03:13

Intermolecular Forces

19.4K
19.4K
Intermolecular Forces in Solutions02:28

Intermolecular Forces in Solutions

40.7K
The formation of a solution is an example of a spontaneous process, a process that occurs under specified conditions without energy from some external source.
When the strengths of the intermolecular forces of attraction between solute and solvent species in a solution are no different than those present in the separated components, the solution is formed with no accompanying energy change. Such a solution is called an ideal solution. A mixture of ideal gases (or gases such as helium and argon,...
40.7K
Theories of Dissolution: Diffusion Layer Model01:15

Theories of Dissolution: Diffusion Layer Model

2.1K
Dissolution, the process by which drug particles dissolve in a solvent, is explained by the diffusion layer model, a theoretical framework that simulates the absorption of oral drugs and allows us to analyze experimental data.
This process starts with a thin layer, saturated with the drug, forming at the interface between the solid and liquid. The solute then diffuses from this layer into the main solution. The Noyes-Whitney equation suggests that the rate of dissolution relies on the diffusion...
2.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The suboptimal clinical applicability of prognostic prediction models for severe postpartum hemorrhage: a meta-epidemiological study.

Journal of clinical epidemiology·2024
Same author

Development and validation of a nomogram for predicting cancer-specific survival in small-bowel adenocarcinoma patients using the SEER database.

World journal of surgical oncology·2024
Same author

4EBP1-mediated SLC7A11 protein synthesis restrains ferroptosis triggered by MEK inhibitors in advanced ovarian cancer.

JCI insight·2024
Same author

Correlative Super-resolution Optical and Electron Microscopic Imaging of Intracellular Ribosomal RNA by a Terpyridine Iridium(III) Complex.

ACS sensors·2024
Same author

Evaluation of droplet digital polymerase chain reaction by detecting cell-free deoxyribonucleic acid in pleural effusion for the diagnosis of tuberculous pleurisy: a multicentre cohort study.

Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases·2024
Same author

Association of prealbumin with short-term and long-term outcomes in patients with acute ST-segment elevation myocardial infarction.

Journal of geriatric cardiology : JGC·2024

Related Experiment Video

Updated: Mar 16, 2026

Synthesis of Cyclic Polymers and Characterization of Their Diffusive Motion in the Melt State at the Single Molecule Level
06:55

Synthesis of Cyclic Polymers and Characterization of Their Diffusive Motion in the Melt State at the Single Molecule Level

Published on: September 26, 2016

8.5K

Interfacial Diffusion and Bonding in Multilayer Polymer Films: A Molecular Dynamics Simulation.

Meinong Shi1, Youchen Zhang1, Lisheng Cheng1

  • 1College of Mechanical and Electrical Engineering and ‡State Key Laboratory of Organic-Inorganic Composites, Beijing University of Chemical Technology , Beijing 100029, P. R. China.

The Journal of Physical Chemistry. B
|August 25, 2016
PubMed
Summary

Multilayer polymer films exhibit distinct interfacial diffusion and bonding behaviors. Molecular dynamics simulations reveal two diffusion stages, impacting mechanical properties like ultimate tensile stress.

More Related Videos

Single-Molecule Diffusion and Assembly on Polymer-Crowded Lipid Membranes
10:43

Single-Molecule Diffusion and Assembly on Polymer-Crowded Lipid Membranes

Published on: July 19, 2022

3.0K
Author Spotlight: Advancing Cell Membrane Biophysics - Exploring Interactions and Challenges Through Experimental and Computational Approaches
07:31

Author Spotlight: Advancing Cell Membrane Biophysics - Exploring Interactions and Challenges Through Experimental and Computational Approaches

Published on: September 1, 2023

3.4K

Related Experiment Videos

Last Updated: Mar 16, 2026

Synthesis of Cyclic Polymers and Characterization of Their Diffusive Motion in the Melt State at the Single Molecule Level
06:55

Synthesis of Cyclic Polymers and Characterization of Their Diffusive Motion in the Melt State at the Single Molecule Level

Published on: September 26, 2016

8.5K
Single-Molecule Diffusion and Assembly on Polymer-Crowded Lipid Membranes
10:43

Single-Molecule Diffusion and Assembly on Polymer-Crowded Lipid Membranes

Published on: July 19, 2022

3.0K
Author Spotlight: Advancing Cell Membrane Biophysics - Exploring Interactions and Challenges Through Experimental and Computational Approaches
07:31

Author Spotlight: Advancing Cell Membrane Biophysics - Exploring Interactions and Challenges Through Experimental and Computational Approaches

Published on: September 1, 2023

3.4K

Area of Science:

  • Materials Science
  • Polymer Science
  • Computational Chemistry

Background:

  • Multilayer nanostructures composed of ultrathin polymer films are crucial for diverse technological applications.
  • Understanding interfacial phenomena, including diffusion and bonding, is key to optimizing their performance.

Purpose of the Study:

  • To investigate the interfacial diffusion and bonding characteristics of multilayer polymer films.
  • To elucidate the relationship between molecular behavior and macroscopic mechanical properties.

Main Methods:

  • Coarse-grained molecular dynamics simulations were employed.
  • Analysis of interfacial diffusion stages and molecular mobility.
  • Characterization of interfacial bonding strength via tensile stress-strain curves.

Main Results:

  • Two distinct stages of interfacial diffusion were identified, with the initial stage being three times faster.
  • Polymers at interfaces show significantly higher in-plane than out-of-plane mobility.
  • Multilayer films exhibit multiple yielding points, differing from bulk behavior.
  • Ultimate tensile stress and separating strain did not consistently increase with diffusion time.

Conclusions:

  • Interfacial diffusion dynamics are strongly influenced by molecular conformation evolution.
  • Nonuniform interlayer interpenetration, driven by molecular rotation and extension, can negatively impact mechanical strength.
  • The findings provide insights into designing robust multilayer polymer nanostructures.