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Human Envelope Following Responses to Amplitude Modulation: Effects of Aging and Modulation Depth.

Andrew Dimitrijevic¹, Jamal Alsamri, M Sasha John

¹1Communication Sciences Research Center, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA; currently at Department of Otolaryngology-Head and Neck Surgery, Sunnybrook Health Sciences Centre, University of Toronto, 2075 Bayview Avenue, Toronto, Ontario, M4N 3M5, Canada; 2Department of Otolaryngology, Biomedical Engineering and Cognitive Sciences, University of California, Irvine, California, USA; 3Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, Ontario, Canada; Rotman Research Institute, Baycrest Centre, Toronto, Ontario, Canada; and 4National Centre for Audiology, Western University, London, Ontario, Canada; School of Communication Sciences and Disorders, Western University, London, Ontario, Canada.

Ear and Hearing

|August 25, 2016

Summary

Objective electrophysiological measures, envelope following responses (EFRs), were compared to behavioral thresholds for amplitude modulation (AM) detection in young and older adults. Older adults showed reduced neural dynamic range, suggesting age-related auditory encoding decline.

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Area of Science:

Auditory Neuroscience
Electrophysiology
Psychoacoustics

Background:

Envelope following responses (EFRs) provide objective measures of auditory processing.
Amplitude modulation (AM) depth detection is crucial for understanding speech intelligibility.
Aging can impact auditory processing, but objective measures need comparison with behavioral data.

Purpose of the Study:

To record EFRs to amplitude-modulated noise with varying AM depth.
To compare EFRs with subjective behavioral thresholds in young and older adults.
To investigate the effect of age on auditory encoding of AM depth.

Main Methods:

Three groups participated: young normal-hearing (YNH), older (O1), and older (O2).
Electrophysiology: EFRs were recorded using swept and fixed AM depth techniques.
Psychophysics: A 3-alternative forced choice (3-AFC) procedure assessed AM detection thresholds.

Main Results:

Significant correlation (r=0.48) found between behavioral and physiological AM detection thresholds.
Older subjects (O2) exhibited a reduced neural dynamic range and plateau levels.
EFR phase slope correlated significantly with pure-tone threshold at 4 kHz.

Conclusions:

Swept AM EFR recordings offer valuable suprathreshold information.
Aging diminishes the auditory system's ability to encode subtle AM depth differences.
The behavioral-physiological AM threshold relationship, while significant, may lack clinical utility for individuals without temporal deficits.