Related Experiment Video

Updated: Mar 16, 2026

Modeling Encephalopathy of Prematurity Using Prenatal Hypoxia-ischemia with Intra-amniotic Lipopolysaccharide in Rats
07:36

Modeling Encephalopathy of Prematurity Using Prenatal Hypoxia-ischemia with Intra-amniotic Lipopolysaccharide in Rats

Published on: November 20, 2015

12.0K

Maternal and neonatal factors related to prematurity

Laura Leismann de Oliveira1, Annelise de Carvalho Gonçalves2, Juvenal Soares Dias da Costa3,4

  • 1Universidade Federal do Rio Grande do Sul, Hospital de Clínicas de Porto Alegre, Porto Alegre, RS, Brazil.

Revista Da Escola De Enfermagem Da U S P
|August 25, 2016
PubMed

Insights

Maternal age, education, multiple pregnancies, and inadequate prenatal care are key factors linked to prematurity. Immediate consequences include low birth weight and poor Apgar scores, highlighting the need for targeted interventions.

Area of Science:

  • Public Health
  • Neonatal Research
  • Epidemiology

Background:

  • Prematurity is a significant global health concern with severe neonatal outcomes.
  • Identifying associated maternal and neonatal factors is crucial for developing effective prevention strategies.

Purpose of the Study:

  • To investigate maternal and neonatal factors associated with preterm birth in Porto Alegre.
  • To understand the determinants of prematurity in a specific urban population.

Main Methods:

  • Population-based case-control study involving 19,457 births in Porto Alegre (2012).
  • Cases: newborns < 37 weeks gestation; Controls: newborns ≥ 37 weeks gestation.
  • Logistic regression analysis applied to sociodemographic, reproductive history, and gestational/birth factors.

Main Results:

  • Statistically significant associations found for: maternal age extremes ( <19 or >34 years), inadequate maternal education, multiple pregnancies, C-section, low birth weight (<2,500g), low Apgar scores (0-3 at 5 min), and inadequate prenatal care.
  • Low birth weight (OR=4.04) and low Apgar scores (OR=1.47) were immediate neonatal consequences.
  • Maternal age, education, multiple gestation, prenatal care, and C-section identified as potential distal determinants.

Conclusions:

  • Prematurity is strongly associated with immediate adverse neonatal outcomes like low birth weight and poor Apgar scores.
  • Maternal age, education, multiple gestation, inadequate prenatal care, and C-section are significant risk factors for prematurity.
  • Findings underscore the importance of addressing these factors for preterm birth prevention.
Abstract

More Related Videos

A Rat Model of Mild Intrauterine Hypoperfusion with Microcoil Stenosis06:19

A Rat Model of Mild Intrauterine Hypoperfusion with Microcoil Stenosis

Published on: January 7, 2018

11.0K
Modeling Ascending Vaginal Infection, Preterm Birth, and Neonatal Morbidity in Mice04:18

Modeling Ascending Vaginal Infection, Preterm Birth, and Neonatal Morbidity in Mice

Published on: October 10, 2025

637

Related Concept Videos

Teratogenicity01:07

Teratogenicity

The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...
4.4K
Factors Affecting Pulmonary Ventilation01:19

Factors Affecting Pulmonary Ventilation

Besides the pressure difference between the external environment and the lungs, the airflow rate and ease of pulmonary ventilation are also influenced by three other factors: surface tension of the fluid in the alveoli, compliance of the lungs, and airway resistance.
Alveolar Surface Tension
The alveolar fluid lines the luminal surface of the alveoli and exerts a force called surface tension. This force is caused by the polar water molecules in the liquid being more strongly attracted to each...
3.6K
Pathophysiology of Diabetes01:20

Pathophysiology of Diabetes

Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
4.1K
Factors Affecting Protein-Drug Binding: Patient-Related Factors01:29

Factors Affecting Protein-Drug Binding: Patient-Related Factors

Protein-drug binding, a pivotal aspect of pharmacokinetics, is subject to considerable variability influenced by an array of patient-related factors. The intricate interplay of age, individual differences, and pathological conditions significantly impact the binding dynamics and subsequent pharmacological effects.
Age stands as a key determinant in protein-drug binding. Neonates, characterized by low albumin content, experience heightened concentrations of unbound drugs such as phenytoin and...
399
Factors Affecting Illness01:18

Factors Affecting Illness

When a person's physical, emotional, intellectual, social development or spiritual functioning is compromised, this deviation from a healthy normal state is called illness. Illness creates stress that in turn harms individuals. Irritation, anger, denial, hopelessness, and fear are behavioral and emotional changes an individual experiences in the phases of illness. A variety of factors influence a person's health and well-being.
For instance, risk factors are connected to illness,...
5.6K
Factors Affecting Drug Response: Overview01:21

Factors Affecting Drug Response: Overview

When it comes to infants and young children, they are typically administered smaller doses of medication in comparison to adults. This is primarily because their organ functions still need to fully develop, meaning their bodies are not as efficient at metabolizing or eliminating drugs. Additionally, their blood-brain barrier is more permeable than in adults. As a result, high concentrations of drugs can easily penetrate the central nervous system (CNS), potentially leading to neurological...
3.2K