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Autoimmune Disorders

Autoimmune Disorders

Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune...

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Updated: Mar 16, 2026

Induction and Diverse Assessment Indicators of Experimental Autoimmune Encephalomyelitis

Induction and Diverse Assessment Indicators of Experimental Autoimmune Encephalomyelitis

Published on: September 9, 2022

[Autoimmune encephalitis].

Albrecht Günther, Julia Schubert, Dirk Brämer

Deutsche Medizinische Wochenschrift (1946)

|August 25, 2016

Summary

This summary is machine-generated.

Autoimmune encephalitis involves brain inflammation from antibodies damaging neurons. Early symptoms include fatigue and fever, progressing to severe neurological issues requiring intensive care.

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Area of Science:

Neuroimmunology
Neurology
Inflammatory Diseases

Background:

Autoimmune encephalitis is an inflammatory brain condition caused by antibodies targeting neuronal structures.
It is classified into onconeuronal antibodies (intracellular antigens) and cell surface protein antibodies (synaptic encephalopathies).

Observation:

Anti-NMDA-Receptor-Encephalitis, the most common type, presents in distinct phases.
Initial symptoms are nonspecific (fatigue, fever, headache), followed by neuropsychiatric issues, seizures, memory loss, coma, and autonomic dysfunction.
Complications like status epilepticus often necessitate intensive care.

Findings:

Diagnosis relies on detecting autoantibodies in serum or cerebrospinal fluid.
An intensive search for tumors is recommended.

Implications:

Treatment involves immunomodulatory and immunosuppressive strategies.
Tumor therapy is crucial for autoimmune encephalitis associated with onconeuronal antibodies.