Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Factors Influencing Drug Absorption: Pharmaceutical Parameters01:28

Factors Influencing Drug Absorption: Pharmaceutical Parameters

709
Solid dosage forms such as tablets and capsules undergo rigorous manufacturing processes to ensure stability and effectiveness. Their dissolution and absorption properties are influenced significantly by the choice of excipients (inactive ingredients that serve various roles in the formulation), and the methodology applied during production. The manufacturing parameters, such as compression force and granulation techniques, significantly affect dissolution rates. Elevated compression forces...
709
Biopharmaceutical Factors Influencing Drug Product Design: Overview01:22

Biopharmaceutical Factors Influencing Drug Product Design: Overview

405
Rational drug product design integrates knowledge of the drug’s physicochemical properties, formulation components, manufacturing techniques, and intended route of administration. Each factor influences the drug’s performance, including how it is released, absorbed, and eliminated in the body.The physicochemical properties of a drug—such as solubility, stability, and particle size—affect its compatibility with excipients and the choice of dosage form. Excipients, though...
405
Factors Affecting Dissolution: Drug Permeability, Stability and Stereochemistry01:20

Factors Affecting Dissolution: Drug Permeability, Stability and Stereochemistry

648
Orally administered drugs primarily enter the systemic circulation via passive diffusion through the intestinal membranes. The drug's absorption is influenced by drug stability in the gastrointestinal GI tract, membrane permeability, the surface area available for absorption, luminal drug concentration, and residence time in the lumen. Drug permeability can be enhanced by adjusting the lipophilicity, polarity, or molecular size of the drug, promoting its passive transport across intestinal...
648
Site-Targeted Drug Delivery Systems: Polymeric Carriers01:24

Site-Targeted Drug Delivery Systems: Polymeric Carriers

79
Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
79
Pharmaceutical Alternatives: Excipients and Impurities-Related Therapeutic Nonequivalence01:19

Pharmaceutical Alternatives: Excipients and Impurities-Related Therapeutic Nonequivalence

220
Pharmaceutical products contain more than just the active drug; they also contain various excipients such as binders, solubilizers, stabilizers, preservatives, and other elements. In some cases, impurities or contaminants might be present. Traditionally, quality control in pharmaceuticals has primarily focused on the analysis of the active drug, often overlooking the impact of these additional components. The recent issue with heparin contamination by over-sulfated chondroitin sulfate, a...
220
Pharmaceutical Alternatives: Polymorphic Form-Related and Particle Size-Related Therapeutic Nonequivalence01:27

Pharmaceutical Alternatives: Polymorphic Form-Related and Particle Size-Related Therapeutic Nonequivalence

211
Changes in polymorphic forms can significantly influence the bioavailability of poorly soluble drugs. Although the FDA defines pharmaceutical equivalence based on having the same active ingredient, dosage form, and route of administration, it does not automatically disqualify products with different polymorphic forms. This means two products with different polymorphs can still be deemed pharmaceutically equivalent. However, polymorphic differences can affect properties like wettability,...
211

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Collisionless ion-electron energy exchange in magnetized shocks.

Physical review. E·2026
Same author

Measurement of ion acceleration and diffusion in a laser-driven magnetized plasma.

Nature communications·2026
Same author

Glucagon-like peptide-1 receptor agonists for treatment of diabetes and obesity: advantage of oral delivery.

Frontiers in drug delivery·2025
Same author

[Analysis of prostate cancer screening results and exploration of screening model for elderly males in Songjiang Rural Areas of Shanghai City based on PSA preliminary screening under the community linkage mode].

Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine]·2025
Same author

Pump depletion and the Raman gap in ignition-scale plasmas.

Physical review. E·2024
Same author

[<i>Pterocarya hupehensis</i> Skan total flavones ameliorate rheumatoid arthritis in rats by suppressing formation of neutrophil extracellular traps].

Nan fang yi ke da xue xue bao = Journal of Southern Medical University·2024

Related Experiment Video

Updated: Mar 15, 2026

A Package of Established Analytical Tools to Investigate the Solid-State Alteration of Lipid-Based Excipients
11:27

A Package of Established Analytical Tools to Investigate the Solid-State Alteration of Lipid-Based Excipients

Published on: August 9, 2022

2.6K

A Molecular Basis for Innovation in Drug Excipients.

J J Irwin1, J Pottel1, L Zou2

  • 1Department of Pharmaceutical Chemistry & QB3 Institute, University of California, San Francisco, California, USA.

Clinical Pharmacology and Therapeutics
|August 25, 2016
PubMed
Summary

Drug formulation excipients play vital roles but their systemic effects are unknown. This study reviews excipient properties, introduces a new database, and proposes methods to explore their molecular actions.

More Related Videos

Production of Near-Infrared Sensitive, Core-Shell Vaccine Delivery Platform
06:27

Production of Near-Infrared Sensitive, Core-Shell Vaccine Delivery Platform

Published on: October 20, 2020

5.7K
Solubility of Hydrophobic Compounds in Aqueous Solution Using Combinations of Self-assembling Peptide and Amino Acid
05:08

Solubility of Hydrophobic Compounds in Aqueous Solution Using Combinations of Self-assembling Peptide and Amino Acid

Published on: September 20, 2017

17.8K

Related Experiment Videos

Last Updated: Mar 15, 2026

A Package of Established Analytical Tools to Investigate the Solid-State Alteration of Lipid-Based Excipients
11:27

A Package of Established Analytical Tools to Investigate the Solid-State Alteration of Lipid-Based Excipients

Published on: August 9, 2022

2.6K
Production of Near-Infrared Sensitive, Core-Shell Vaccine Delivery Platform
06:27

Production of Near-Infrared Sensitive, Core-Shell Vaccine Delivery Platform

Published on: October 20, 2020

5.7K
Solubility of Hydrophobic Compounds in Aqueous Solution Using Combinations of Self-assembling Peptide and Amino Acid
05:08

Solubility of Hydrophobic Compounds in Aqueous Solution Using Combinations of Self-assembling Peptide and Amino Acid

Published on: September 20, 2017

17.8K

Area of Science:

  • Pharmacology and Pharmaceutical Sciences
  • Drug Delivery Systems
  • Medicinal Chemistry

Background:

  • Excipients are essential components in pharmaceutical formulations, critical for drug stability, release, and patient acceptance.
  • Despite their widespread use and importance, the systemic availability and molecular interactions of excipients remain largely uncharacterized.
  • Understanding excipient behavior is crucial for optimizing drug product performance and safety.

Purpose of the Study:

  • To review the known properties of pharmaceutical excipients.
  • To introduce a novel, publicly accessible database for cataloging excipient information.
  • To outline a strategic approach for investigating the direct molecular activities of excipients.

Main Methods:

  • Comprehensive literature review of excipient properties and functions.
  • Development and curation of a public database for excipient enumeration and categorization.
  • Proposal of a research strategy for exploring excipient-target interactions.

Main Results:

  • Key properties and roles of common excipients are summarized.
  • A new database is presented, offering a centralized resource for excipient data.
  • A framework is proposed for future research into excipient pharmacology.

Conclusions:

  • Excipients, while critical for drug formulation, possess largely unexplored systemic activities.
  • The developed database serves as a valuable resource for researchers.
  • Further investigation into excipient molecular actions is warranted to enhance drug development.