Related Experiment Video
Updated: Mar 15, 2026
Isolation and Characterization of a Head and Neck Squamous Cell Carcinoma Subpopulation Having Stem Cell Characteristics
Published on: May 11, 2016
CD73 is associated with poor prognosis in HNSCC
Zhen-Hu Ren1,2, Cheng-Zhong Lin1,2, Wei Cao1,2
1Department of Oral Maxillofacial-Head and Neck Oncology, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China.
High CD73 expression indicates poor survival in Head and Neck Squamous Cell Carcinoma (HNSCC). CD73 promotes HNSCC migration, invasion, and tumorigenesis, suggesting it as a therapeutic target.
Area of Science:
- Oncology
- Immunology
- Cell Biology
Background:
- CD73 is an immunosuppressive enzyme linked to tumor progression.
- The prognostic value of CD73 in Head and Neck Squamous Cell Carcinoma (HNSCC) is not well-defined.
Purpose of the Study:
- To investigate the prognostic significance of CD73 in HNSCC.
- To explore the functional role of CD73 in HNSCC progression.
Main Methods:
- Gene and protein expression analyses in HNSCC patient samples.
- In vitro functional assays for cell migration and invasion.
- In vivo xenograft studies for tumorigenesis.
Main Results:
- Elevated CD73 expression correlates with reduced overall survival in HNSCC patients.
- CD73 enhances HNSCC cell migration and invasion via adenosine A3R and EGF/EGFR signaling.
- CD73 promotes tumor growth in vivo.
Conclusions:
- CD73 serves as a poor prognostic marker for HNSCC patient survival.
- CD73 represents a potential therapeutic target for HNSCC treatment.
More Related Videos
06:11Therapy Testing in a Spheroid-based 3D Cell Culture Model for Head and Neck Squamous Cell Carcinoma
Published on: April 20, 2018
07:29Intramucosal Inoculation of Squamous Cell Carcinoma Cells in Mice for Tumor Immune Profiling and Treatment Response Assessment
Published on: April 22, 2019
