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Yeast Signaling

Yeast Signaling

Yeasts are single-celled organisms, but unlike bacteria, they are eukaryotes (cells with a nucleus). Cell signaling in yeast is similar to signaling in other eukaryotic cells. A ligand, such as a protein or a small molecule released from a yeast cell, attaches to a receptor on the cell surface. The binding stimulates second-messenger kinases to activate or inactivate transcription factors that further regulate gene expression. Many of the yeast intracellular signaling cascades have similar...

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Sensory input attenuation allows predictive sexual response in yeast.

Alvaro Banderas^1,2, Mihaly Koltai¹, Alexander Anders¹

¹Max Planck Institute for Terrestrial Microbiology &LOEWE Research Center for Synthetic Microbiology (SYNMIKRO), Karl-von-Frisch-Str. 16, D-35037 Marburg, Germany.

Nature Communications

|August 26, 2016

Summary

Budding yeast, Saccharomyces cerevisiae, adjusts sexual reproduction based on mate availability. Pheromone signaling and degradation by Bar1 allow yeast to sense sex ratio and optimize mating fitness.

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Area of Science:

Cell biology
Evolutionary biology
Microbiology

Background:

Animals adjust sexual behavior based on mate competition.
Unicellular eukaryotes like yeast also exhibit mating behaviors.

Purpose of the Study:

To investigate if yeast, Saccharomyces cerevisiae, regulates mating behavior in response to mate competition.
To elucidate the mechanism of sex-ratio sensing in yeast.

Main Methods:

Studied pheromone-based communication between yeast mating types.
Investigated input attenuation by recipient cells.
Analyzed the role of the peptidase Bar1 in pheromone degradation.

Main Results:

Yeast robustly monitors relative mate abundance (sex ratio).
Yeast adjusts commitment to sexual reproduction based on estimated mating success.
Bar1-mediated pheromone degradation is key to sex-ratio sensing.

Conclusions:

Yeast exhibits adaptive regulation of mating behavior in response to population sex ratio.
Pheromone degradation by Bar1 provides an adaptive advantage by optimizing mating fitness.
This study explains the adaptive significance of pheromone degradation in yeast mating.