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Neutrophil Isolation and Analysis to Determine their Role in Lymphoma Cell Sensitivity to Therapeutic Agents
Published on: March 25, 2016
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Neutrophils in cancer
Louise W Treffers1, Ida H Hiemstra1, Taco W Kuijpers1,2
1Sanquin Research, and Landsteiner Laboratory, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.
Immunological Reviews
|August 26, 2016
Summary
Neutrophils have complex roles in cancer, acting as both pro- and anti-tumorigenic cells. Understanding these functions, including their role as myeloid-derived suppressor cells (MDSC), can improve cancer immunomodulation and treatment.
Area of Science:
- Oncology
- Immunology
Background:
- Neutrophils are crucial in cancer, influencing progression and therapy monitoring.
- Their presence in blood and tumor tissue has prognostic value.
- Neutrophils exhibit both pro- and anti-tumorigenic activities.
Purpose of the Study:
- To review the multifaceted roles of neutrophils in cancer.
- To explore their dual functions in tumor progression and immunotherapy.
- To highlight their impact on the tumor microenvironment.
Main Methods:
- Literature review of neutrophil functions in cancer.
- Analysis of neutrophil roles as myeloid-derived suppressor cells (MDSC).
- Examination of neutrophil effector functions in antibody therapy.
Main Results:
- Neutrophil roles are complex and heterogeneous, varying by cancer type and stage.
- Neutrophils can promote cancer progression, e.g., as MDSC.
- Neutrophils exert protective effects, especially during antibody immunotherapy.
Conclusions:
- Neutrophils significantly impact cancer progression through direct and indirect mechanisms.
- Targeting neutrophils offers potential for cancer immunomodulation.
- Further understanding of neutrophils can lead to improved cancer patient treatments.
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