New Adamantyl Chalcones: Synthesis, Antimicrobial and Anticancer Activities

Area of Science:

• Medicinal Chemistry
• Organic Synthesis
• Antimicrobial Research

Background:

• Chalcones are a class of natural compounds with diverse biological activities.
• Adamantyl chalcones represent a novel structural class with potential therapeutic applications.

Purpose of the Study:

• To synthesize and characterize a new series of adamantyl chalcones.
• To evaluate the antimicrobial and anticancer activities of these novel compounds.

Main Methods:

• Claisen-Schmidt reaction for synthesis of adamantyl chalcones.
• Spectroscopic data (NMR, Mass Spectrometry) and X-ray crystallography for structural confirmation.
• In vitro antimicrobial assays against Gram-positive and Gram-negative bacteria and pathogenic fungi.
• In vitro antitumor assays against human pancreas cancer cell line (Miapaca2).

Main Results:

• A series of adamantyl chalcones (2, 3a-o) were synthesized in good yields.
• Compounds demonstrated significant antibacterial activity against *Enterococcus faecali*, *Pseudomonas aeruginosa*, and *Escherichia coli*.
• Notable antifungal activity was observed against *Candida glabrata*.
• The synthesized chalcones exhibited anticancer activity against Miapaca2 cells.

Conclusions:

• Adamantyl chalcones are a promising scaffold for developing new antimicrobial agents.
• These compounds warrant further investigation for their potential as anticancer therapeutics, particularly for pancreatic cancer.