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Melatonin and Respiratory Diseases: A Review
Solomon Habtemariam, Maria Daglia, Antoni Sureda
1Applied Biotechnology Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran.
Current Topics in Medicinal Chemistry
|August 26, 2016
Summary
Melatonin, a potent antioxidant, shows therapeutic promise for various respiratory conditions. This review explores its molecular mechanisms in treating lung diseases like asthma and COPD.
Area of Science:
- Biochemistry
- Pharmacology
- Pulmonology
Background:
- Melatonin is a multifunctional indoleamine with diverse biological activities.
- Its effects include antioxidant, anti-inflammatory, and neuroprotective properties.
- Melatonin influences cellular processes by inhibiting NF-κβ and MMP-3.
Purpose of the Study:
- To systematically review the therapeutic potential of melatonin in respiratory diseases.
- To elucidate the molecular mechanisms underlying melatonin's actions in lung conditions.
Main Methods:
- Systematic literature review.
- Analysis of scientific reports on melatonin's efficacy in respiratory conditions.
- Examination of molecular pathways involved in melatonin's therapeutic effects.
Main Results:
- Melatonin demonstrates potential in treating asthma, respiratory infections, COPD, lung cancer, and vascular pulmonary diseases.
- Its therapeutic effects are linked to modulating redox status and inhibiting pro-inflammatory mediators.
- Molecular mechanisms involve NF-κβ inhibition and MMP-3 down-regulation.
Conclusions:
- Melatonin exhibits significant therapeutic potential for a range of respiratory diseases.
- Its multifaceted molecular actions underscore its promise as a treatment option.
- Further research into melatonin's role in pulmonology is warranted.
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